Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (41): 7759-7762.doi: 10.3969/j.issn.1673-8225.2011.41.040

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Effects of fluid shear stress on Wnt/β-catenin signal transduction pathway in fibroblasts

Tang Yuan, Xia Ya-yi   

  1. Institute of Orthopedics, Second Hospital of Lanzhou University, Lanzhou   730030, Gansu Province, China
  • Received:2011-02-16 Revised:2011-03-16 Online:2011-10-08 Published:2011-10-08
  • Contact: Xia Ya-yi, Doctor, Institute of Orthopedics, Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China xiayayi@yahoo.com.cn
  • About author:Tang Yuan★, Master, Institute of Orthopedics, Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China tangyuan@souhu. Com
  • Supported by:

    the Natural Science Foundation of Gansu Province*

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Abstract:

BACKGROUND: Mechanical stimulation exerts an important role in effects of Wnt/β-catenin signal transduction pathway on differentiation, proliferation and apoptosis of fibroblasts.
OBJECTIVE: To explore the role of fluid shear stress in promoting bone formation and fracture healing influenced by Wnt/β-catenin signal transduction pathway.
METHODS: A computer-based retrieval was performed in CNKI and PubMed database to search the manuscripts regarding fluid shear stress published between January 1990 and December 2009
RESULTS AND CONCLUSION: 43 papers were included in the final analysis. Mechanically stimulating Wnt/β-catenin signal transduction pathway can increase the sensitivity to bone formation of LRP5 G171V mouse cells and increase bone mass and bone density. The in vivo and in vitro mechanical loading results support that Wnt/β-catenin signaling is a normal physiological response to load and that activation of the Wnt/β-catenin pathway enhances the sensitivity of osteoblasts/osteocytes to mechanical loading.

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