Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (41): 7755-7758.doi: 10.3969/j.issn.1673-8225.2011.41.039

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Application of platelet-rich plasma in treatment of bone repair

Chen Jian, Yuan Wen, Song Dian-wen   

  1. Department of Orthopedics, Changzheng Hospital, Second Military Medical University of Chinese PLA, Shanghai  200003, China
  • Received:2011-04-19 Revised:2011-04-28 Online:2011-10-08 Published:2011-10-08
  • Contact: Song Dian-wen, Doctor, Associate professor, Department of Orthopedics, Changzheng Hospital, Second Military Medical University of Chinese PLA, Shanghai 200003, China aspirin_cj@yahoo.com.cn
  • About author:Chen Jian☆, Doctor, Attending physician, Department of Orthopedics, Changzheng Hospital, Second Military Medical University of Chinese PLA, Shanghai 200003, China chenjianhz@hotmail.com
  • Supported by:

    the National Natural Science Foundation of China, No.30970735*

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Abstract:

BACKGROUND: Platelet-rich plasma (PRP) is capable to enhance the repair of many kinds of tissue. It is now more and more used to treat the bone or soft tissue deficiency in orthopedic clinics.
OBJECTIVE: To summarize the new progress of PRP and its applications in orthopedics in recent years.
METHODS: A compute-based online search of Pubmed database from January 1999 to January 2011 and China National Knowledge Infrastructure from January 1999 to January 2011 was performed using the key words of “platelet-rich plasma, bone formation, tissue engineering”. The experimental studies about PRP and clinical applications in orthopedics were included. Repeated or out-of-date studies were excluded. Totally, 301 articles were collected and finally 48 were included according to inclusion and exclusion criteria.
RESULTS AND CONCLUSION: Although with controversy, PRP is a promising technique, especially as scaffold of tissue engineering. It would be very helpful in development of bone tissue engineering. Besides standardized the research protocol by evidence-based medicine, it should be a very important research direction.

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