Abstract:

BACKGROUND: At present, the methods for treatment of articular cartilage defects have obvious shortcomings. Tissue-engineered cartilage for repair of articular cartilage defects provides a novel method to treat cartilage defects with minimal invasion.
OBJECTIVE: To summarize the research progress in tissue-engineered cartilage for repair of articular cartilage degects.
METHODS: A computer-based retrieval was performed by the first author in the Wanfang data (2000/2010)and Pubmed database (2000/2010) using the key words “articular cartilage defects, tissue-engineered cartilage” in English and Chinese. The development and construction of tissue-engineered cartilage were summarized. A total of 666 manuscripts were searched. According to inclusion and exclusion criteria, 23 manuscripts were included in the final analysis.
RESULTS AND CONCLUSION: With increasing development of cell scaffold material and tissue construction technique, tissue-engineered cartilage of active cells and scaffold material provides a novel therapeutic method for treatment of articular cartilage defects with minimal invasion, so tissue-engineered cartilage for treatment of cartilage defects is completely feasible, and C-GP gel has good compatibility with seeded cells and can be used as the ideal scaffold for tissue-engineered cartilage. But preparation and selection of cell scaffold remains a difficult problem for tissue-engineered cartilage.