Abstract:

BACKGROUND: Measuring important basic data of experimental animals is the important basis for standardization and management of experimental animals.
OBJECTIVE: To measure and compare organ weight, organ coefficient, hematological parameters and hematological biochemical parameters of specific pathogen free (SPF) Balb/c mice.
METHODS: A total of 240 Balb/c mice were fed for 1 week and then organ weights, organ coefficient, hematological parameters and hematological biochemical parameters were measured.
RESULTS AND CONCLUSION: There were significant differences in weights of the heart, lung, spleen, double kidneys, and bladder between female and male Balb/c mice (P < 0.01 or P < 0.05). There were significant differences in organ coefficient of lung, spleen, double kidneys and bladder between female and male Balb/c mice (P < 0.01 or P < 0.05). There were significant differences in leukocyte, monocytes, basophils, monocytes (%), eosinophils, basophils (%), erythrocyte, hemoglobin, mean corpuscular hemoglobin concentration, and red blood cell distribution width between female and male Balb/c mice (P < 0.01 or    P < 0.05). There were significant differences in total protein, albumin, A/G, glucose, urea nitrogen, creatinine, uric acid, triglycerides, total cholesterol, low density lipoprotein, high density lipoprotein, iron, and phosphorus between female and male Balb/c mice(P < 0.01 or P < 0.05). These results suggest that gender has influences on organ weight, organ coefficient, hematological parameters and hematological biochemical parameters of SPF Balb/c mice.