Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (41): 7661-7664.doi: 10.3969/j.issn.1673-8225.2011.41.015

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Heat shock protein 70 expression after Shenfu injection administration in a rat model of cerebral ischemia/reperfusion injury   

Jiang Cheng-ping1, Liu Fu1, Li Yi1, Wang Bai-qiang1, Tang Xiao-rong1, Wu Bi-hua2, Wang Xiao-ming2   

  1. 1Department of Pharmacology, Affiliated Hospital of North Sichuan Medical College, Nanchong  637007, Sichuan Province, China
    2Neurology Research Institute, North Sichuan Medical College, Nanchong  637007, Sichuan Province, China
  • Received:2011-07-07 Revised:2011-08-29 Online:2011-10-08 Published:2011-10-08
  • Contact: Wu Bi-hua, Professor, Doctor, Master’s supervisor, Neurology Research Institute, North Sichuan Medical College, Nanchong 637007, Sichuan Province, China
  • About author:Jiang Cheng-ping, Associate chief physician, Department of Pharmacology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637007, Sichuan Province, China chengpingjiang@ sina.cn
  • Supported by:

    a grant from Department of Science and Technology of Sichuan Province, No. 2010JY0094*

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Abstract:

BACKGROUND: Shenfu injection plays a protective effect on ischemia/reperfusion injury in improving microcirculation and increasing blood oxygen content in tissue.
OBJECTIVE: To investigate the effects of Shenfu injection on heat shock protein 70 (Hsp70) expression in a rat model of cerebral ischemia/reperfusion injury.
METHODS: SD rats were randomly divided into three groups (n=32 for each group): sham-operated, middle cerebral artery occlusion (MCAO), and Shenfu injection.
RESULTS AND CONCLUSION: Shenfu injection improved the arrangement of brain nerve cells, reduced the swelling of cell bodies and pyknosis at 1 day after administration. At 3 days after Shenfu injection administration, a more obvious trend on the attenuation of the above phenomena was observed. At 1 and 3 days, Hsp70 expression was significantly higher in the Shenfu injection group than in the sham-operated and MCAO groups. These finding suggest that Shenfu injection exhibits a significant protective effect on cerebral ischemia/reperfusion injury, and this protective effect may be implemented by increasing Hsp70 expression.

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