Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (41): 7639-7642.doi: 10.3969/j.issn.1673-8225.2011.41.010

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Establishment of a rabbit model of knee joint osteoarthritis combined with osteoporosis

Zhou Jun1, 2, He Cheng-qi1, 2, Guo Hua1, 2, Xia Lu1, 2, Qin Yu-xi1, 2, Liu Hui-fang1, 2   

  1. 1Sichuan Province Key Laboratory of Rehabilitation Medicine，Chengdu  610041, Sichuan Province, China
    2Department of  Rehabilitation, West China Hospital, Sichuan University, Chengdu  610041, Sichuan Province, China
  • Received:2011-04-18 Revised:2011-04-26 Online:2011-10-08 Published:2011-10-08
  • Contact: He Cheng-qi, Doctor, Professor, Chief physician, Sichuan Province Key Laboratory of Rehabilitation Medicine, Department of Rehabilitation, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China hechqi@yahoo.com.cn
  • About author:Zhou Jun☆, Studying for doctorate, Sichuan Province Key Laboratory of Rehabilitation Medicine, Department of Rehabilitation, West China Hospital, Sichuan University Chengdu 610041, Sichuan Province, China kxj1980@yahoo.com.cn

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Abstract:

BACKGROUND: Clinical studies have shown that there are a large proportion of patients suffering from osteoarthritis (OA) combined with osteoporosis (OP). Now the relationship between OA and OP is disputed. So an animal model of OA combined with OP is beneficial to prevention and treatment of OA combined with OP and also facilitates to understand the relationship between OA and OP.
OBJECTIVE: To establish an animal model of OA combined with OP.
METHODS: Fourteen white New Zealand rabbits were randomly divided into a normal control group (NC group) and an ovariectomy group (OVX group). The OVX group rabbits underwent bilateral ovariectomy. The NC group rabbits received no treatments.
RESULTS AND CONCLUSION: At 10 weeks after OVX, the OVX group rabbits showed obvious articular cartilage degeneration and serum estrogen and femoral bone mineral density were significantly decreased, while articular cartilage Mankin scores were significantly increased compared with the NC group (P < 0.01). Articular cartilage Mankin scores were negatively correlated with serum estrogen, while bone mineral density was positively correlated with serum estrogen. These results showed that a rabbit model of OA combined with OP of the knee joint can be successfully established by OVX.

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