Abstract:

BACKGROUND: When osteoporotic bone strength decreases, slight trauma or other risk factors would cause fracture.
OBJECTIVE: To observe the changes in trabecular bone, bone mineral density and bone mineral apposition rate during osteoporotic fracture healing.
METHODS: Sprague-Dawley rats were randomly divided into osteoporosis and control groups. Rats from osteoporosis group underwent bilateral ovariectomy and 3 months later, fracture model was created. At 4, 8, 12 and 16 weeks after fracture, dynamic parameters of bone reconstruction were determined using fluorescence microscope, and bone mineral density of callus was determined using dual-energy X-ray absorptiometry. At 1, 2, 4, 6, 8, 12 and 16 weeks after fracture, bone histomorphology was measured using automatic image system.
RESULTS AND CONCLUSION: Compared with the control group, the ratio of mature trabecular bone to callus was lower, trabecular bone thickness was less, distance between trabecular bones was greater, percentage of trabecular bone surface fluorescence labeling and bone mineral density in callus were lower, but bone mineral apposition rate was higher, in the osteoporosis group. Results showed that abnormal changes of callus microanatomy result in decreased mechanical strength or quality of fractured bone during osteoporotic fracture healing.