Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (41): 7607-7610.doi: 10.3969/j.issn.1673-8225.2011.41.002

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Effects of psoralea corylifolia on alveolar bone absorption in an ovariectimized rat model of periodontitis

Zhu Jian-hua1, Chi Yu-hong2, Zhang Yan-qiu1, Liu Ji-guang3   

  1. 1Stomatology Hospital, Jiamusi University, Jiamusi  1540007, Heilongjiang Province, China
    2Department of Stomatology, Third Affiliated Hospital, Qiqihar Medical University, Qiqihar  161000, Heilongjiang Province, China
    3Office of Science and Technology, Jiamusi  1540007, Heilongjiang Province, China
  • Received:2011-04-19 Revised:2011-06-20 Online:2011-10-08 Published:2011-10-08
  • Contact: Liu Ji-guang, Doctor, Professor, Office of Science and Technology, Jiamusi 1540007, Heilongjiang Province, China Liujg5550@163.com
  • About author:Zhu Jian-hua, Professor, Stomatology Hospital, Jiamusi University, Jiamusi 1540007, Heilongjiang Province, China zhu8622877@yahoo.com.cn
  • Supported by:

    Science and Technology Research Program of Ministry of Education of China, No.205041*

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Abstract:

BACKGROUND: Psoralea corylifolia exhibits obvious therapeutic effects on osteoporosis.
OBJECTIVE: To investigate the effects of psoralea corylifolia on alveolar bone metabolism, alveolar bone mineral density and height in ovariectimized rats with periodontitis.
METHODS: Thirty female Wister rats were randomly divided into three groups: ovariectomy, psoralea corylifolia and sham-surgery. Rats from the ovariectomy and psoralea corylifolia groups underwent bilateral ovariectomy, and rats from the sham surgery group did not receive ovariectomy. At 2 days after ovariectomy, rats from the psoralea corylifolia group were orally administered 3 g/kg psoralea corylifolia, once a day. At 2 weeks after ovariectomy, all rats were established into peridontitis models by ligation of maxillary molar.
RESULTS AND CONCLUSION: At 12 weeks after ligation of maxillary molar, compared with sham surgery group, estradiol and calcium ion levels were significantly decreased (P < 0.05), alkaline phosphatase level was significantly increased (P < 0.05) in the ovariectomy group. X-ray and hematoxylin-eosin staining showed that alveolar bone mineral density and height in the ovariectomy group was significantly decreased than that in the control group (P < 0.05). Compared with ovariectomy group, serum level of calcium ion was significantly increased (P < 0.05) and alkaline phosphatase level was significantly decreased    (P < 0.05), and alveolar bone mineral density and height were significantly increased in the psoralea corylifolia group. However, no significant difference was observed between psoralea corylifolia group and sham surgery group (P > 0.05). These findings suggest that estrogen-deficient state can promote alveolar bone absorption in rats with experimental periodontitis, and psoralea corylifolia can prevent the decrease in alveolar bone height and density resulting from estrogen deficiency.

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