Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (38): 7193-7196.doi: 10.3969/j.issn.1673-8225.2011.38.039

Previous Articles     Next Articles

Research progress and clinical application of sustained-release drugs

Aihemaitijiang1, Yu Yong-fu2, Huang Xiang-zeng3   

  1. 1First Department of Internal Medicine, Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi  830000, Xinjiang Uygur Autonomous Region, China
    2Department of ICU, Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi  830011, Xinjiang Uygur Autonomous Region, China
    3Second Department of Internal Medicine, Second Affiliated Hospital of Xinjiang Medical University, Urumqi  830028, Xinjiang Uygur Autonomous Region, China
  • Received:2011-05-30 Revised:2011-06-25 Online:2011-09-17 Published:2011-09-17
  • Contact: Huang Xiang-zeng, Master, Associate chief physician, Second Department of Internal Medicine, Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830028, Xinjiang Uygur Autonomous Region, China hexiaoxiao2010@ sina.com
  • About author:Aihemaitijiang, Attending physician, First Department of Internal Medicine, Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China yeuopod@xj.cniafo.net

PDF

647

Abstract:

BACKGROUND: Currently, there are over 40 kinds of slow-release materials available for the production, which are widely used in clinic.
OBJECTIVE: To review several important drug carrier materials in the world as well as sustained-release drugs commonly used in clinic.
METHODS: A computer search of CNKI and PubMed databases (2000-01/2010-12) were conducted for articles addressing sustained-release drugs. The keywords were “sustained release, drug, biomaterials” in Chinese and English. Meta analysis and repetitive studies were excluded. Finally, 23 articles were included in result analysis.
RESULTS AND CONCLUSION: Biodegradable synthetic polymer materials have become highly valued and widely used. Chitosan has become widely accepted for its good performance, as an important carrier of drug delivery; polylactic acid, a biodegradable polymer, plays an important treatment role in drug delivery; fibrin glue with high biocompatibility can effectively delay the drug release, which is widely used in many clinical areas.

CLC Number: