Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (38): 7181-7184.doi: 10.3969/j.issn.1673-8225.2011.38.036

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Different scaffolds with mesenchymal stem cells to construct tissue engineered ligament in anterior cruciate ligament injury

Liu Wei, Chen Shi-rong   

  1. Department of Orthopedics, Second Affiliated Hospital of Chongqing Medical University, Chongqing  400010, China
  • Received:2010-12-02 Revised:2011-05-11 Online:2011-09-17 Published:2011-09-17
  • Contact: Chen Shi-rong, Associate professor, Master’s supervisor, Department of Orthopedics, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China chensr128@sina.com
  • About author:Liu Wei★, master’s degree, Department of Orthopedics, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China liuweifreeman@yahoo.com.cn

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Abstract:

BACKGROUND: Anterior cruciate ligament (ACL) is a strong, dense structure connecting femur and tibia. It is important for forward stability of the knee joint. ACL injury may cause knee joint unstable. If it does not have proper treatment, cartilage, meniscus and other structural may have secondary injury.
OBJECTIVE: To review the application of different scaffolds with mesenchymal stem cells (MSCs) in treating ACL injury.
METHODS: PubMed database was researched by computer o search articles published from 1950-01 to 2010-11 with key words of “ACL, stem cells, MSC, tendon, ligament”. Totally 103 papers were selected, and 35 articles were included in final analysis.
RESULTS AND CONCLUSION: Tissue-engineered ligament constructed with mesenchymal stem cells and scaffolds is successfully used in animal experiements. MSCs can significantly speed up the repair of ligament damage and strengthen the biomechanical properties of healed tissue, but the biomechanical properties of regenerated tissue has not yet reached the level of normal tendon. At the same time, MSCs can promote the healing of the ligament-bone enthesis, prevent failure due to ligament-bone nonunion after ACL reconstruction. To select the appropriate MSCs, scaffold, mechanical stimulation and necessary cytokines is the key to construct tissue engineered ligament. With the development of tissue engineering and scaffold materials, MSCs constructed tissue engineered ligament will be soon introduced from basic research to clinical application.

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