Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (38): 7177-7180.doi: 10.3969/j.issn.1673-8225.2011.38.035

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Burst release and control of the delivery system of protein/peptide drug loaded poly(lactic-co-glycolic acid) microspheres

Zhao Xian-ying1, Gao Ji-ning2, Su Yong-ping2, Liu Yi-min1, Xiao Xiang1   

  1. 1Department of Chemistry, College of Laboratory Medicine and Pharmacy, Third Military Medical University, Chongqing  400038, China
    2Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, Third Military Medical University, Chongqing  400038, China
  • Received:2011-03-04 Revised:2011-04-29 Online:2011-09-17 Published:2011-09-17
  • Contact: Gao Ji-ning, Doctor, Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, Third Military Medical University, Chongqing 400038, China
  • About author:Zhao Xian-ying★, Master, Professor, Department of Chemistry, College of Laboratory Medicine and Pharmacy, Third Military Medical University, Chongqing 400038, China xianyingzhao@yahoo.com.cn

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Abstract:

BACKGROUND: Burst release is key technology that limits the wide application of protein/peptide microspheres. It should be a problem to be solved.
OBJECTIVE: To make a detailed introduction about burst release reason, influence factors and reduction methods after analyzing recent progress of burst release and control of protein/peptide drug loaded poly(lactic-co-glycolic acid) (PLGA).  
METHODS: Relevant articles in PubMed and CNKI published 1999-01/2010-12 were searched by computer with the key words of “PLGA, peptide, protein, microspheres, burst release, control” in Chinese and English. Articles addressing originally identification, reliability, general analysis, and high correlation were included. Exclusive criteria: repetitive and obsolescent articles. A total of 24 articles were reserved for review.
RESULTS AND CONCLUSION: We need to comprehend mechanism of burst release of protein/peptide microspheres to realize enlargement application. Burst release was influenced by multifactors, such as characters of PLGA, preparation methods and preparation parameters. Burst release could be reduced some degree by the control of the above mentioned. It is very important to research of new drugs.

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