Abstract:

BACKGROUND: Bone histomorphometry is a quantitative histological examination of an undecalcified bone biopsy performed to obtain quantitative information on bone remodeling and structure. It has been widely used in the development of mechanisms in metabolic bone disease, anti-osteoporosis drugs and other research in recent years.
OBJECTIVE: To review bone histomorphometry from it was aware of clinical research to clinical applications and prospects, to clarify its application and research status in clinical bone diseases.
METHODS: A computer of CNKI database (2000-2010) and PubMed database (1965-2010) was performed by the first author using “bone histomorphometry, metabolic bone diseases, bone biopsy, bone remodeling, humans” in Chinese and English as the key words, to retrieve relevant literatures about the research of bone histomorphometry in clinical bone disease, Finally, 30 literatures were included for analysis.
RESULTS AND CONCLUSION: The results show that the bone histomorphometry is of indispensable value and significance in clinical use and effective assessment. Bone histomorphometry has an important role in bone structure, bone metabolism, bone biology pathology, bone and bone-reactive protein and other drugs in several directions, multidisciplinary research.