Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (35): 6602-6606.doi: 10.3969/j.issn.1673-8225.2011.35.034

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Cell transplantation and tissue engineering reconstruction of nucleus pulposus in the treatment of intervertebral disc degeneration 

Chen Qing-he, Ye Jun-jian   

  1. Department of Orthopedics, First Affiliated Hospital of Fujian Medical University, Fuzhou  350005, Fujian Province, China
  • Received:2011-04-19 Revised:2011-05-23 Online:2011-08-27 Published:2011-08-27
  • Contact: Ye Jun-jian, Professor, Department of Orthopedics, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China yejunjian@medmail.com.cn
  • About author:Chen Qing-he★, Studying for master’s degree, Department of Orthopedics, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China johny_chan@yahoo.cn
  • Supported by:

    the Matural Science Foundation of Fujian Province, No.c710010*; Academic Development Fund for Professors in Fujian Province, No.js9007*

Abstract:

BACKGROUND: It is the best ideal therapy for degenerative disc diseases to implant cells or cell scaffold complex into the degenerated disc so as to improve the regeneration of the intervertebral disc.
OBJECTIVE: To evaluate the clinical effect and prospect of in vivo transplantation of nucleus pulposus cells for degenerative disc diseases.
METHODS: The first author retrieved PubMed, CNKI, and Wanfang databases for articles about tissue engineering nucleus pulposus, tissue engineering materials and bone marrow mesenchymal stem cells for treatment of degenerative disc diseases published from 1990 to 2010.
RESULTS AND CONCLUSION: The common scaffolds include collagen scaffold, agarose scaffold, alginate scaffold, polyglycolic acid scaffold, chitosan scaffold and composite scaffold. By gene screening technique, the seed cells were selected from autologous disc cells or mesenchymal stem cells. Then, the cells and/or cell scaffold complex transplantation was for synthesis of regenerated extracellular matrix. It provides a new therapeutic strategy for functional recovery of degenerated disc through the reversal and restoration of intervertebral disc cells.

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