Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (35): 6466-6470.doi: 10.3969/j.issn.1673-8225.2011.35.002

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Local application of ibandronate enhances early fixation of implants X-ray, histomorphology and biomechanical pull-out tests 

Lu Qiu-dong1, Hu Wen-hai2, Li Cheng-li2, Hu Tong-yu2   

  1. 1People’s Hospital of Ninghe County, Tianjin  301500, China
    2Third Hospital of Hebei Medical University, Shijiazhuang  050010, Hebei Province, China
  • Received:2011-03-08 Revised:2011-06-13 Online:2011-08-27 Published:2011-08-27
  • Contact: Hu Wen-hai, Master, Chief physician, Professor, Third Hospital of Hebei Medical University, Shijiazhuang 050010, Hebei Province, China
  • About author:Lu Qiu-dong, Attending physician, People’s Hospital of Ninghe County, Tianjin 301500, China luqiudong_1980@163.com

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Abstract:

BACKGROUND: The aseptic loosening of prosthesis has become one of the most obvious matters after operation of prosthesis replacement.  
OBJECTIVE: To verify the effect of ibandronate on early fixation of implants by local application.
METHODS: Forty-four Zelanian rabbits were used in the experiment. A standard animal model of the rabbits’ both tibia was embedded with metal screw into the proximal end. Ibandronate at 1 mg/L was sprinkled locally in the left tibia of every rabbit (experimental group), while saline solution was given in the right tibia (control group).
RESULTS AND CONCLUSION: ①X-ray showed that, the light-gap around the screw of the experimental group was remarkably narrower than that in control group in weeks 2, 4, 8 after model establishment; there were more new bones observed around the screw of experimental groups in weeks 4, 8 compared with control group. ②Histomorphology showed that in week 2, the width of the fiber membrane in control group was more thicker than in experimental group (P< 0.001); In weeks 4 and 8, the new bone mass (%) of experimental group was obviously higher than that of control group (P < 0.001). ③Biomechanical pull-out test showed that, the maximal shear strength (Pm) of experimental group was significantly higher than that of control group in weeks 4 and 8 (P < 0.001). These findings indicate that, local application of ibandronate solution can obviously promote new bone formation at the earlier period, improve early fixation of implants and decrease the incidence of aseptic loosening of prosthesis. 

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