Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (34): 6453-6456.doi: 10.3969/j.issn.1673-8225.2011.34.045

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Autologous platelet-rich gel for the repair of facial burn wounds of degree Ⅱ in children

Chen Fu-lu1, Li Hong-mian2, Han Liang-shu1   

  1. 1Department of Surgery, Zhaoping  County Peoples’ Hospital, Hezhou  546800, Guangxi Zhuang Autonomous Region, China
    2Department of Plastic and Aesthetic Surgery, Zhongshan Hospital of Sun Yat-sen University, Zhongshan  528403, Guangdong Province, China
  • Received:2010-12-23 Revised:2011-01-29 Online:2011-08-20 Published:2011-08-20
  • Contact: Li Hong-mian, Doctor, Associate chief physician, Department of Plastic and Aesthetic Surgery, Zhongshan Hospital of Sun Yat-sen University, Zhongshan 528403, Guangdong Province, China binrong2112@163.com
  • About author:Chen Fu-lu, Attending physician, Department of Surgery, Zhaoping County Peoples’ Hospital, Hezhou 546800, Guangxi Zhuang Autonomous Region, China

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Abstract:

BACKGROUND: Platelet-rich plasma can be formed the gel combined with thrombin. It not only sticks together with the tissue defected area but also prevents to the platelet run off, so the platelet excrete growth factors to keep on a long time at the local tissue. So the autologous platelet-rich gel (APG) can be avoid some shortcomings of the liquid recombinant human epidermal growth factor (rhEGF) run off and easily evaporated on wounds.
OBJECTIVE: To observe the therapeutic effect of APG during the repair for the children facial burn wounds of degree Ⅱ.
METHODS: Thirty cases of children (< 14 years old) facial burn of superficial degree Ⅱ and 30 cases of facial burn patients of deep degree Ⅱ were selected, who were treated in the Department of Burn and Plastic Surgery, the Guangxi Zhaoping Pepole’s Hospital between January 2008 and January 2010. They were divided into treatment group (left face) and control group (right face). At the 3rd day after burn, the patients in the treatment group were treated with APG directly on the wounds and half exposure, the dressing change was once a day till the wounds healed and those in the control group were treated with normal saline gauzes half exposure, the dressing change was once a day till the sounds healed. The healing ratio of wounds, healing time, pain, scar and adverse reaction were observed in both groups at 7 and 14 days. The pain was assessed by the visual analog score (VAS). The wounds scar hyperplasia of deep degree Ⅱ (scar index) was detected by the modified Vancouver scar measurement.
RESULTS AND CONCLUSION: For the facial burn of superficial degree Ⅱ at 7 days, the healing ratio in the treatment group was significantly higher than that in the control group (P < 0.05), and the healing time was obviously shorter than that in the control group (P < 0.05). For the facial burn patients of deep degree Ⅱ at 14 days, the healing ratio in the treatment group was significantly higher than that in the control group (P< 0.05), the healing time was obviously shorter than that in the control group (P < 0.05), and the scar index was lower than that in the control group (P < 0.05). There were no obvious differences in the pain score of two kinds of wounds between the two groups. External APG can significantly accelerate the healing speed, shorten the healing time on the children facial burn wounds of degree Ⅱ and can promote the healing quality with less scars formation, and without obvious adverse effect.

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