Abstract:

BACKGROUND: Newtype sustained-release and controlled release formulations accelerate the development of drug formulations.
OBJECTIVE: To summarize the techniques and clinical applications of currently used oral sustained-release and controlled-release formulations.
METHODS: Using "sustained-release, controlled-release, biopharmaceutics, drug delivery, polymer" in Chinese of “delayed release, drug delivery carrier, polymer material, contraled release” in Eenlish as key words in the title and abstracts, a computer retrieval of CNKI and PubMed database at 2000-02/2011-04 was performed for articles on oral sustained-release and controlled-release drugs. Language was limited to English and Chinese. Articles related to the polymer medicinal materials, technology and clinical application of sustained-release and controlled-release drug formulations were included, repetitive articles were excluded.
RESULTS: The ideal dosage form requires a high selectivity of drugs on the target site, efficacy in delaying the necessary time, then rapidly and completely excretes, has no adverse reactions to other organs and tissues. In the design of sustained-release formulations, it need to fully consider the water-solubility of drugs, oil-water partition coefficient, chemical stability, protein binding rate and other physical and chemical properties and biological properties. Physiological factors are still important for sustained-release preparations, such as site of administration, gastrointestinal peristalsis, first-pass effect, blood supply, patient’s disease state, target organ.