Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (34): 6399-6402.doi: 10.3969/j.issn.1673-8225.2011.34.032

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Biological security of silver nanoparticles and their use in denture base resin

Lü Qiao, Yang Li-na, Guo Wei, Zheng Xin-ying, Li Qing-yan, Gao Ning   

  1. Department of Prosthodontics, West China College of Stomatology, Sichuan University, Chengdu  610041, Sichuan Province, China
  • Received:2011-02-06 Revised:2011-03-20 Online:2011-08-20 Published:2011-08-20
  • Contact: Gao Ning, Doctor, Professor, Department of Prosthodontics, West China College of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China mr.gao-ning@163.com
  • About author:Lü Qiao★, Studying for master’s degree, Department of Prosthodontics, West China College of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China lvqiao_1985@yahoo.com.cn
  • Supported by:

    the Program of Sichuan Science and Technology Bureau, No. 2008SG0023*

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Abstract:

BACKGROUND: In recent years, silver nanoparticles have been widely used in medicinal and biological fields. What is more, silver nanoparticle antibacterial agents have a wide antimicrobial spectrum, long lasting effect, non-drug tolerance as well as the fine physical-chemistry properties. As more and more nano-silver products have been developed, their bio-safety researches have gradually attracted people’s attention.
OBJECTIVE: To review the biological security of silver nanoparticles, and to preliminarily analyze its antibacterial effect in the denture resin base as well as the influence on the properties of the resin.
METHODS: A computer based retrieve of the articles related to silver-based inorganic antimicrobial agent and its application in the denture base resin was performed in CNKI, PubMed and OVID databases during 2000 to 2010. Finally, 30 representative literatures in Chinese and English was included for further analysis.
RESULTS AND CONCLUSION: When we discuss the biological safety of nano-silver on this issue, we should take all these into consideration rather than toxic or nontoxic, such as the shape, particle size, dose, etc. In addition, the nano-silver has strong antibacterial function especially to the common oral pathogen，such as Streptococcus mutans, Lactobacillus oris, Canidia albicans. This function can be used in the prevention and treatment of denture stomatitis. But how to overcome the base oxidation discoloration still remains to be further studied.

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