Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (34): 6395-6398.doi: 10.3969/j.issn.1673-8225.2011.34.031

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Preparation, burst release and influencing factors of poly(lactic-co-glycolic acid) microspheres

Wang Xi1, Xue Jing2, Huang Yue-shan2, Zhi Xiao-xing2   

  1. 1Guangdong Food and Drug Vocational College, Guangzhou  510520, Guangdong Province, China
    2College of Bioscience and Bioengineering, South China University of Technology, Guangzhou  510006, Guangdong Province, China
  • Received:2010-12-09 Revised:2011-01-09 Online:2011-08-20 Published:2011-08-20
  • Contact: Huang Yue-shan, Associate professor, College of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, Guangdong Province, China xuejing2088@163.com
  • About author:Wang Xi, Associate professor, Guangdong Food and Drug Vocational College, Guangzhou 510520, Guangdong Province, China zheng5@sina.com
  • Supported by:

    the Natural Science Foundation of Guangdong Province, No. 9151052005000006

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Abstract:

BACKGROUND: Poly(lactic-co-glycolic acid) (PLGA) is a biocompatible polymer material. PLGA-based microspheres and nanoparticles can improve the stability of drugs, also achieve sustained release, controlled release and targeted release.
OBJECTIVE: To analyze the methods in preparation of PLGA microparticles, and the cause, influencing factors and improvement methods of burst release.
METHODS: A computer-based online research was performed in China Journal Full-text Database and PubMed database published from 1990 to 2010. Articles concerning the preparation and burst release of PLGA microparticles were included.
RESULTS AND CONCLUSION: Currently the methods of preparing PLGA microparticles contain single coagulation, emulsification-curing, spray drying methods. The reasons causing the burst release is primarily a weak interaction between drug molecules and polymer molecules, easily leading to drug release from the microspheres into the release medium, then drug release from the microsphere holes and gaps at the early release stage, thus leading to burst release. The factors influencing burst release are PLGA molecular weight, concentration, drug loading of microspheres, main pharmacological and physico-chemical properties, preparation methods and preparation parameter of microspheres. Although many scholars are still primarily studying the underlying mechanism and controlling measures of burst release, it is believed to reduce the burst release rate of microspheres through proper optimization and control of the influencing factors, thus solving burst release problem.

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