Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (34): 6388-6392.doi: 10.3969/j.issn.1673-8225.2011.34.029

Previous Articles     Next Articles

Application of gene-activated-matrix in the repair of orthopaedic tissue injury

Yan Yun-fei1, Wang Rui2, Zhao Jian-ning2   

  1. 1Clinical Medical College of Nanjing University, Department of Orthopaedics, Nanjing General Hospital of Nanjing Military Area Command of Chinese PLA, Nanjing  210002, Jiangsu Province, China
    2Department of Orthopaedics, Nanjing General Hospital of Nanjing Military Area Command of Chinese PLA, Nanjing  210002, Jiangsu Province, China
  • Received:2011-02-14 Revised:2011-03-20 Online:2011-08-20 Published:2011-08-20
  • Contact: Zhao Jian-ning, Professor, Chief physician, Doctoral supervisor, Department of Orthopaedics, Nanjing General Hospital of Nanjing Military Area Command of Chinese PLA, Nanjing 210002, Jiangsu Province, China zhaojianning.0207@163.com
  • About author:Yan Yun-fei★, Studying for master’s degree, Clinical Medical College of Nanjing University, Department of Orthopaedics, Nanjing General Hospital of Nanjing Military Area Command of Chinese PLA, Nanjing 210002, Jiangsu Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81000792*

PDF

393

Abstract:

BACKGROUND: Gene-activated-matrix (GAM) is a new kind of transgenic matrix designed for tissue engineering. At present GAM is used for repairing of nonunion, cartilaginous injury, ligament and tendon injury in orthopaedics.
OBJECTIVE: To analyze the application of GAM in the repair of orthopaedic tissue injury, and to provide reference for further clinical application of GAM in orthopedics
METHODS: “Gene-Activated-Matrix, GAM” in English and “gene-Activated-Matrix, GAM, tissue engineering, bone and cartilage injury repair, ligament and tendon injury repair” in Chinese were utilized as search terms to retrieve 128 literatures from CNKI database and PubMed database (1999-01/2010-09). The researches related to basic, prospective, and clinical study of bone tissue engineering and GAM were included, standard duplicate researches were excluded, 26 of them were involved for analysis.
RESULTS AND CONCLUSION: GAM is currently mainly used for the repair of fractures, cartilage, and tendon and ligament injury. With the development of molecular biology and genetic engineering technology, GAM can be used to repair articular cartilage injury, the target cells by transgenic continued high secretion of growth factors to repair articular cartilage injury. Currently, the main problems of gene therapy are the safety of gene transfer, the controllability of gene expression, and appropriate gene vector. Meanwhile, GAM treatment also provides a new therapeutic approach for the healing of ligament and tendon injuries. Numerous studies showed that GAM treatment has efficacy and feasibility in tissue injury repair, but still faces many problems to be solved.

CLC Number: