Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (34): 6346-6350.doi: 10.3969/j.issn.1673-8225.2011.34.019

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Repair of artificial enamel lesions by nano fluorapatite paste containing fluorin

Wang Cheng-jie1, 2, Zhang Yi-fei1, 2, Wei Jie2, 3, Wei Shi-cheng1,2   

  1. 1Department of Oral and Maxillofacial Surgery, Laboratory of Interdisciplinary Studies, Peking University School of Stomatology, Beijing  100081, China
    2Center for Biomedical Materials and Tissue Engineering, Academy for Advanced  Interdisciplinary Stuides, Peking University, Beijing  100871, China
    3Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai  200237, PR China
  • Received:2011-04-14 Revised:2011-06-07 Online:2011-08-20 Published:2011-08-20
  • Contact: Wei Jie, Doctor, Associate researcher, Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Stuides, Peking University, Beijing 100871, China; Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China nic7505@263.net Correspondence to: Wei Shi-cheng, Doctor, Professor, Department of Oral and Maxillofacial Surgery, Laboratory of Interdisciplinary Studies, Peking University School of Stomatology, Beijing 100081, China; Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Stuides, Peking University, Beijing 100871, China sc-wei@pku.edu.cn
  • About author:Wang Cheng-jie★, Studying for master’s degree, Department of Oral and Maxillofacial Surgery, Laboratory of Interdisciplinary Studies, Peking University School of Stomatology, Beijing 100081, China; 2Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Stuides, Peking University, Beijing 100871, China dentist_wangcj@163.com
  • Supported by:

    the National 973 Program of China, No. 2007CB936103*

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Abstract:

BACKGROUND: Enamel-like crystals could grow on human tooth by application of the neutral (pH 7.5) nano-fluorapatite paste.
OBJECTIVE: To evaluate the effect of nano fluorapatite paste with addition of 1 mg/L fluorin on the repair of artificial enamel lesions.
METHODS: Enamel blocks with artificially-induced lesions by 17% phosphate acid solution were randomly divided into two groups that were respectively coated with neutral (pH 7.5) nano-fluorapatite pastes with two different content of fluorin (the group without addition of fluoride ions was set as the controlled group, the other one with addition of 1 mg/L fluoride ions was set as the experimental group) for 15 minutes at 37 ℃. Scanning electronic microscope, XRD, XPS and Vickers micro-hardness test were performed for the enamels before and after treatment.
RESULTS AND CONCLUSION: A layer of enamel-like fluoride substituted hydroxyapatite was observed on the surface of all the samples, but the crytallinity of the experimental group was obviously higher than that of natural enamel and controlled group. But the crystallinity and Vicker micro-hardness of the experimental group was higher than the controlled group obviously (P < 0.05), and the surfaces were smoother. The results indicated the fluorinion had significant effect on the repair of enamel lesion by neutral (pH 7.5) nano-fluorapatite pastes at improvement of Vickers micro-hardness, crystallinity and smoothness of the enamel.

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