Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (34): 6281-6284.doi: 10.3969/j.issn.1673-8225.2011.34.003

Previous Articles     Next Articles

Polylactic-co-glycolic acid-tricalcium phosphate-bone morphogenetic protein-2 artificial bone combined with muscle transplantation for repair of bone defects

Xu Jian-qiang, Zhou Mi, Zhang Shu-ming, Li Chang-geng, Yang Fei, Sun Suo-zhu, Wang Chang-jiang, Wang Ke-li   

  1. Department of Orthopaedics, Second Artillery General Hospital of PLA, Beijing  100088, China
  • Received:2010-12-17 Revised:2011-02-07 Online:2011-08-20 Published:2011-08-20
  • Contact: Zhang Shu-ming, Professor, Master’s supervisor, Department of Orthopaedics, Second Artillery General Hospital of PLA, Beijing 100088, China zsmep@tom.com
  • About author:Xu Jian-qiang☆, Doctor, Associate chief physician, Department of Orthopaedics, Second Artillery General Hospital of PLA, Beijing 100088, China Zhou Mi☆, Doctor, Attending physician, Department of Orthopaedics, Second Artillery General Hospital of PLA, Beijing 100088, China mimizhou1975@ yahoo.com.cn Xu Jian-qiang and Zhou Mi contributed equally to this paper.
  • Supported by:

    “Tenth Five-Year” Medical Scientific Research Foundation of PLA, No. 06G018*

PDF

481

Abstract:

BACKGROUND: Large segmental bone defects are mostly repaired by bone graft. If the tissue with blood life and artificial bone were simultaneously implanted into bone defects, which are theoretically more conducive to the construction of new tissue blood life and reconstruction of artificial bone creeping substitution.
OBJECTIVE: To observe the effects of the composite of polylactic-co-glycolic acid-tricalcium phosphate-bone morphogenetic protein-2 (PLGA-TCP-BMP-2) artificial bone combined with vascularized muscle transplantation in repairing the large segmental defect.
METHODS: A 30 mm defect was made in large segment of sheep's radius. The experiment was randomly divided into 3 groups. Experimental group was implanted into PLGA-TCP-BMP-2 artificial bone and vascularized long flexor of digits; control group was only implanted into PLGA-TCP-BMP-2 artificial bone; no material was implanted into blank group. Plates were used to fix the bone in 3 groups, and then underwent X ray detection and histological observation at 24 weeks after operation.
RESULTS AND CONCLUSION: Bone defect of radius was fully repaired with clear contour of cortical bone and medullary cavity, callus was mature lamellar bone in experimental group. While in control group, the contour was not as clearly as in experimental group. No effective callus was found and the defect area filled with abundant fibrous tissue in blank group. PLGA-TCP-BMP-2 artificial bone combined with vascularized muscle transplantation can repair large segmental defect of 30 mm sheep’s radius satisfactorily.

CLC Number: