Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (29): 5367-5370.doi: 10.3969/j.issn.1673-8225.2011.29.012

Previous Articles     Next Articles

Sheng Ji Yu Hong collagen matrices for repair of skin wound

Yan Ting-ting1, Xiong Meng2, Zhou Yong2, Yao Chang2   

  1. 1Department of Plastic Surgery, Zhongda Hospital, Southeast University, Nanjing  210009, Jiangsu Province, China
    2Department of General Surgery, Jiangsu Hospital of Traditional Chinese Medicine, Nanjing  210009, Jiangsu Province, China
  • Received:2011-03-07 Revised:2011-05-09 Online:2011-07-16 Published:2011-07-16
  • Contact: Yao Chang, Associate chief physician, Department of General Surgery, Jiangsu Hospital of Traditional Chinese Medicine, Nanjing 210009, Jiangsu Province, China
  • About author:Yan Ting-ting★, Studying for master’s degree, Department of Plastic Surgery, Zhongda Hospital, Southeast University, Nanjing 210009, Jiangsu Province, China yan_xiaomao@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30973756*; Leading Talent Project of Traditional Chinese Medicine in Jiangsu Province, No. LJ200902*

PDF

463

Abstract:

BACKGROUND: Sheng Ji Yu Hong collagen matrices can obviously promote wound healing.
OBJECTIVE: To observe the effect of Sheng Ji Yu Hong collagen matrices on rabbit skin wound healing.
METHODS: Three full-thickness skin wounds were made and repaired with Sheng Ji Yu Hong collagen matrices, BFGF agent, normal saline solution, separately. Healing time, healing ratio, number of fibroblasts, hemeoxygenase-1 level, transforming growth factor β1 mRNA and protein expression, and proliferating cell nuclear antigen expression were observed.
RESULTS AND CONCLUSION: Sheng Ji Yu Hong could promote the proliferation of fibroblasts more remarkably than BFGF agent and normal saline (P < 0.05), increase expressions of hemeoxygenase-1 level, transforming growth factor β1 and proliferating cell nuclear antigen (P < 0.05), elevate healing rate (P < 0.05), and shorten healing time (P < 0.05). Sheng Ji Yu Hong collagen matrices can promote skin wound healing obviously, and the mechanism maybe relates to elevate the expression of hemeoxygenase-1 level and transforming growth factor β1, and preserve the activity of prosthetic cells.

CLC Number: