Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (21): 3905-3908.doi: 10.3969/j.issn.1673-8225.2011.21.024

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Effects of bone wax and oxidized regenerated cellulose on the hemostasis of the sternum in elderly women undergoing open heart surgery

Wang Chun, Dong Si-yuan, Gu Tian-xiang, Fang Qin, Song Lai-chun, Yu Lei   

  1. Department of Cardiac Surgery, the First Affiliated Hospital of China Medical University, Shenyang  110001, Liaoning Province, China
  • Received:2011-02-18 Revised:2011-04-23 Online:2011-05-21 Published:2011-05-21
  • Contact: Gu Tian-xiang, Doctor, Professor, Department of Cardiac Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China　 cmugtx@sina.com
  • About author:Wang Chun☆, Doctor, Attending physician, Department of Cardiac Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China　 doctorchun@126.com
  • Supported by:

    the Funding Program of Liaoning Educational Committee, No. 2004C050*; Science and Technology Plan of Liaonign Province, No.2006401013-2*

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Abstract:

BACKGROUND: Oxidized regenerated cellulose has been used in neurological surgery and otolaryngology, but there is no report about oxidized regenerated cellulose applied in heart surgery for sternal bleeding.
OBJECTIVE: To compare the effects of oxidized regenerated cellulose and bone wax on sternal bleeding and infections during open heart surgery in old women.
METHODS: Totally 68 female patients over 60 years undergoing open heart surgery were divided into oxidized regenerated cellulose group and bone wax group. The sternal wound and bone marrow cavity of the former group was filled with oxidized regenerated cellulose and bone wax group with medical bone wax. Recording operating time, cardiopulmonary bypass time, time of closing chest, total drainage volume, re-exploration for bleeding, the volume of blood transfusion, suture removal time, average hospital stay, postoperative sternal wound healing were recorded.
RESULTS AND CONCLUSION: The comparison between two groups in operating time, time of closing chest, total drainage volume, re-exploration for bleeding, the volume of blood transfusion was significantly different (P < 0.05). These indexes were improved dramatically in the oxidized regenerated cellulose group. The mortality, suture removal time, average hospital stay and postoperative sternal wound healing were no significantly different between two groups. Oxidized regenerated cellulose as a new material for sternal hemostasis can be routinely used after cardiopulmonary bypass, and the early results of the study showed its effectiveness and safety.

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