Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (21): 3909-3912.doi: 10.3969/j.issn.1673-8225.2011.21.025

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Effects of hemoperfusion using HA130 resin hemoperfusion apparatus on microinflammatory state in maintenance hemodialysis patients

Zhou Xi-yu1, Song Jie2, Zhang Xiao-dong2, Li Ying2, Li Hui2   

  1. 1Department of Nephrology, Shaanxi Municipal Corps Hospital of Chinese People’s Armed Police Forces, Xi’an  710054, Shaanxi Province, China
    2Department of Nephrology, Affiliated Hospital of Medical College of the Chinese People’s Armed Police Forces, Tianjin  300162, China
  • Received:2011-02-12 Revised:2011-04-11 Online:2011-05-21 Published:2011-05-21
  • Contact: Zhang Xiao-dong, Master, Attending physician, Department of Nephrology, Affiliated Hospital of Medical College of the Chinese People’s Armed Police Forces, Tianjin 300162, China LIHUI2009WUJING@163.com
  • About author:Zhou Xi-yu, Attending physician, Department of Nephrology, Shaanxi Municipal Corps Hospital of Chinese People’s Armed Police Forces, Xi’an 710054, Shaanxi Province, China zxiyu@sohu.com
  • Supported by:

    the Natural Science Foundation of Tianjin, No. 09JCYBJC09900*

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Abstract:

BACKGROUND: Studies have found that the microinflammatory state exists in uremic patients undergoing maintenance hemodialysis (MHD).
OBJECTIVE: To investigate the effects of hemoperfusion using HA130 resin hemoperfusion apparatus on microinflammatory state in MHD patients.
METHODS: Sixty uremia patients undergoing maintenance hemodialysis were divided into two groups: hemoperfusion group (n=30) and MHD group (n=30). Hemoperfusion group underwent the treatment of hemoperfusion using HA130 resin hemoperfusion apparatus combined with hemodialysis. MHD group underwent the treatment of hemodialysis. The serum levels of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL–6) and tumor necrosis factor alpha (TNF-α) of all patients in the two group were detected before and after the treatment.
RESULTS AND CONCLUSION: In the hemoperfusion group, the serum levels of hs-CRP, IL-6 and TNF-α were lower after treatment than those before treatment, and the difference was significant (P < 0.05); In the MHD group, the serum levels of hs-CRP, IL-6 and TNF-α were higher after treatment than those before treatment, and the difference was not significant (P > 0.05). The results indicate that hemoperfusion using HA130 resin hemoperfusion apparatus can reduce the serum levels of hs-CRP, IL-6 and TNF-α and control the microinflammatory state in MHD patients.

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