Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (21): 3867-3870.doi: 10.3969/j.issn.1673-8225.2011.21.016

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Histological and biomechanical evaluation in the interface between nano-surface titanium alloy implants and bone

Huang Cheng-long1, Zhao Chang-li2, Han Pei1, Ji Wei-ping1, Guo Shang-chun1, Jiang Yao1, Zhang Xiao-nong2   

  1. 1Department of Orthopaedics, the Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai  200233, China
    2School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai  200240, China
  • Received:2010-11-27 Revised:2010-12-22 Online:2011-05-21 Published:2011-05-21
  • Contact: Jiang Yao, Master, Chief physician, Professor, Department of Orthopaedics, the Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China jiangyao1951@163.com
  • About author:Huang Cheng-long★, Studying for master’s degree, Department of Orthopaedics, the Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China huangchenglonghcl@163.com
  • Supported by:

    Nano Foundation of Science and Technology Commission of Shanghai Municipality, No 0852nm02800*

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Abstract:

BACKGROUND: Prosthetic looseness is the main cause of arthroplasty failure and revision. Surface treatment of the materials can promote the osseointegration rate and the stability of implants.
OBJECTIVE: To evaluate the osseointergration of nano-surface titanium alloy (Ti6A14V) implant in animals.
METHODS: Novel nanophase Ti6A14V substrates were prepared according to the severe plastic deformation principle. Ti6A14V substrate implants with common surface, hydroxyapatite-coated surface and nanophase surface were transplanted into each femoral intercondylar notch of beagle dogs. Three months later, all the beagle dogs were checked with X-ray film, then sacrificed. The condyles of femur with the implants were taken out, non-decalcification group sections were prepared for Van Gieson staining, bone ingrowth between the interfaces of the bone-implant were studied and kinesics parameter was measured. Pull-out test was applied to compare the shear strength between the interfaces of the bone-implant.
RESULTS AND CONCLUSION: Radiographic examinations showed bone recovery around the implant and no obvious lucent gap in the interface of implant-bone. Histological examination suggested that lots of mature trabecular bone formed around Ti6A14V substrate implants with hydroxyapatite-coated surface and nanophase surface, the interface osseointegration rates showed no difference between them (P > 0.05), but all significantly higher than that of Ti6A14V substrate implants with common surface (P < 0.001). Pull-out test demonstrated that shear strength showed no difference between Ti6A14V substrate implants with hydroxyapatite-coated surface and nanophase surface (P > 0.05), but all significantly stronger than that of Ti6A14V substrate implants with common surface (P < 0.001). Ti6A14V substrate implants with nanophase surface improves the bone-implant osseointegration in vivo as hydroxyapatite-coated surface did, suggesting that novel nanophase Ti6A14V substrates prepared according to the severe plastic deformation principle may has a bone induction activity and might has a prosperous future for implant applications.

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