Abstract:

BACKGROUND: High-porosity polycaprolactone (PCL) nanofiber scaffolds have a good multi-pore structure for the adhesion and proliferation of vascular smooth muscle cells and perfect biocompatibility.
OBJECTIVE: To evaluate the cell biocompatibility of high-porosity PCL scaffold made by electrostatic spinning technology.
METHODS: Electrostatic spinning technology was used to produce high-porosity PCL nanofiber stents. WST-1 method was used to evaluate the effects of scaffold on the adhesion and proliferation of smooth muscle cells cultured with different scaffolds. Light microscope and scanning electron microscope were used to observe the morphology of cells.
RESULTS AND CONCLUSION: The high-porosity PCL scaffold exhibited better biocompatibility than the traditional one in cell morphology, adhesion and proliferation. It is indicated that the high-porosity PCL nanofiber stents produced by electrostatic spinning technology owns better biocompatibility.