Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (19): 3586-3589.doi: 10.3969/j.issn.1673-8225.2011.19.040

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Progress of adipose-derived stem cells in orthopedics research

Chen Lei-jie, Wang Wei, Dang Xiao-qian, Wang Kun-zheng   

  1. Department of Orthopedics, the Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an  710004, Shaanxi Province, China
  • Received:2010-11-15 Revised:2011-02-16 Online:2011-05-07 Published:2011-05-07
  • Contact: Wang Kun-zheng, Doctor, Chief physician, Department of Orthopedics, the Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China wkzh1955@yahoo.com.cn
  • About author:Chen Lei-jie★, Studying for master’s degree, Department of Orthopedics, the Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China chenleijie85@163.com
  • Supported by:

    Guanghua Foundation of Xi’an Jiaotong University, No. 0203204*; Medicine and Engineering Cross-Cooperation Projects of Xi’an Jiaotong University, No. 08143027*

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Abstract:

BACKGROUND: Adipose-derived stem cells (ADSCs) have become increasingly popular since it was discovered, which support a new way to treat orthopedic diseases.
OBJECTIVE: To review the biological characterization and progress of ADSCs in orthopedic basic research, and provide powerful theoretical basis for further basic researches.
METHODS: The first author retrieved ISI Web of knowledge database (http://www.isiknowledge.com) and PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) for articles concerning the biological characterization of ADSCs and restoration of orthopedic diseases extensively published from 2001 to 2010. The key words were “adipose-derived stem cell，orthopaedic”.
RESULTS AND CONCLUSIONS: ADSCs have similar characterization and multipotential differentiation as bone marrow-derived stem cells. Meanwhile, ADSCs reveal excellent results in defect repair of bone, cartilage, intervertebral disk, tendon and ligament. Furthermore, because of the abundance and ease of harvest, ADSCs can support adequate seed cells for cell engineering, tissue engineering and medicine researching. Therefore, ADSCs have manifested broad prospects in therapy of orthopedic diseases, which deserve a further investigation.

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