Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (12): 2249-2252.doi: 10.3969/j.issn.1673-8225.2011.12.039

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Adhesion methods and problems of growth factors in demineralized bone matrix

Ren Zhi-chao1, Wang Xin1, 2, Liu Bao-lin1, 2   

  1. 1Institute of Food Science and Hypothermia, 2Institute of Biological and Thermal Science, School of Medical Instrument and Food Engineering，University of Shanghai for Science and Technology, Shanghai  200093, China
  • Received:2010-09-25 Revised:2010-11-11 Online:2011-03-19 Published:2011-03-19
  • Contact: Wang Xin, Doctor, Associate professor, 1Institute of Food Science and Hypothermia, 2Institute of Biological and Thermal Science, School of Medical Instrument and Food Engineering，University of Shanghai for Science and Technology, Shanghai 200093, China wx0426951@126.com
  • About author:Ren Zhi-chao★, Studying for master’s degree, Institute of Food Science and Hypothermia, School of Medical Instrument and Food Engineering，University of Shanghai for Science and Technology, Shanghai 200093, China renjinzi2003@yahoo.com.cn
  • Supported by:

    the National Natural Science Foundation of China, No. 50776060*; Shanghai Science and Technology Development Funds, No.07QA14042*; New Century Excellent Talents in University, No. NCET-07-0559*; Leading Academic Discipline Project of Shanghai Municipal Education Commission, No. S30503*; Shanghai Eastern Scholar Plan*

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Abstract:

BACKGROUND: As a bio-derived bone engineering scaffolds, demineralized bone matrix (DBM) become more and more popular for its bone formation performance. However, the inherent induced protein of demineralized bone are less, bone inducing activity is limited. The effect of induced bone issue growth was significantly enhanced after demineralized bone combined with growth factor, which is conductive to bone injury and the rehabilitation of patients with bone defects.
OBJECTIVE: To summarize combination method, research progress and the main problems of growth factor in DBM.
METHODS: PubMed (http://www.ncbi.nlm.nih.gov/PubMed) and Wanfang databases (http://www.wanfangdata.com.cn) were retrieved by the first author with the key words of “Demineralized bone, Growth factor, Combination” both in English and Chinese. Articles related to applied research of demineralized bone and growth factor in medicine and the relevant literature on growth factor and demineralized bone combination method were included.
RESULTS AND CONCLUSION: The demineralized bone has excellent biocompatibility, biological activity and biodegradability, which can easily integrate with surrounding bone to support the growth of new bone tissue. The demineralized bone combined with the growth factor, not only can make the growth factor arrive to the bone defect accurately and uniformly, but also promote the growth of bone tissue and it will be more beneficial for bone transplantation and bone defects in rehabilitation of patients. At present, the composite method of the DBM combined with the growth factor still have some problems of loose combination and instable release of growth factors, etc. So the research and exploration of growth factor combined with DBM need to be further strengthened.

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