Abstract:

OBJECTIVE: To summarize the relationship of coronary artery stent material and changes of inflammatory factor after implantation of coronary artery stent material.
METHODS: A computer-based online search of Wanfang database (1998-01/2010-12) was performed with the key words of “coronary artery stent, biocompatibility, inflammatory factor, cytokine, thrombus” in Chinese. Literatures about changes of inflammatory factor after implantation of coronary artery stent material were included, duplicated and Meta-analysis articles were excluded.
RESULTS: The implantation of stents in coronary artery may lead to the injury of coronary artery, and promote the release of inflammatory factors in vivo cells. According to the expression of inflammatory cytokines and cytokine, it can be well reflected local vascular damage degree and inflammation levels after implantation of scaffold. Drug-eluting stents can significantly reduce incidence of restenosis and rate of target lesion revascularization after implantation of stents, and significantly increase the information of late stent thrombosis.
CONCLUSION: Stents contacted with blood and vessel wall can produce inflammation and sensitization reaction after the implantation of stent in vivo, therefore, inflammation and anti-coagulation therapy should be fully controlled before and after the implantation of stents.