Abstract:

OBJECTIVE: To summarize the bionomics and clinical application of artificial bone graft materials at recent years.
METHODS: VIP database was retrieved by the computer, the time was limited to 1998-01/2010-10. The index words were “bone filling material, bone defect, bone tumor, bone disease, bone tissue engineering” in Chinese. Literatures related to the bionomics and clinical application of artificial bone graft materials were included. The data were selected firstly, and each citation was checked in each article. A total of 15 documents were involved for analysis.
RESULTS: Artificial bone graft materials including inorganic material, organic material and composite material. Composite material combined the advantages of inorganic material and organic material, which had good biological safety, biocompatibility, biological activity and biomechanical properties. Artificial bone was implanted into bone defects at limbs fracture internal fixation or after curettage of bone tumors. The healing process of skeleton was accelerated, the incidence of delayed union or disunion was reduced, and which had a great clinical value.
CONCLUSION: Artificial bone graft material is close to autogenous bone in the promotion of bone healing and effect of vertebral fusion, without rejection, and with good biocompatibility.