Abstract:

OBJECTIVE: To summarize the application status of chitosan and derivant in pharmaceutical preparation.
METHODS: VIP database was retrieved by computer, the time was limited to 1999-01/2010-10. The index words were “chitosan, release, drug, application” in Chinese. Articles about the application status of chitosan and derivant in pharmaceutical preparation were included, outdated literatures were excluded. Totally 20 documents were involved for analysis.
RESULTS: Chitosan has a good biocompatibility, biodegradation, avirulent, and easily film-forming. In the field of pharmacy at home and abroad, chitosan was used to the research of release and controlled release preparation attracted people’s attention. The unique physical and chemical properties of chitosan, such as chitosan encounter acid expansion form a gel, have good film-forming and promote the polypeptide, transdermal absorption of protein drugs. Chitosan generally in the form of tablet, film-former, microsphere and microcapsule served as skeleton materials of release and controlled release preparation.
CONCLUSION: Controlled release preparations developed by chitosan can balance the drug release rate and reduce drug side effects of normal tissue cells.