Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (12): 2146-2148.doi: 10.3969/j.issn.1673-8225.2011.12.014

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Preparation of gastrointestinal bioadhesive controlled release tablets using biodegradable Zein

Xie Jun-jun1, Wu Hong-fei1, Lu Chuan-hua1, Zhang Qun-wei1, Lu Tao2   

  1. 1Anhui Province Key Laboratory for R&D of Chinese Medicine, College of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei   230038, Anhui Province, China
    2College of Pharmacy, Anhui Medical University, Hefei   230038, Anhui Province, China
  • Received:2010-09-12 Revised:2010-10-20 Online:2011-03-19 Published:2011-03-19
  • Contact: Lu Chuan-hua, Professor, Anhui Province Key Laboratory for R&D of Chinese Medicine, College of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei 230038, Anhui Province, China lch@ahtcm.edu.cn
  • About author:Xie Jun-jun★, Studying for master’s degree, Anhui Province Key Laboratory for R&D of Chinese Medicine, College of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei 230038, Anhui Province, China sylt214@139.com
  • Supported by:

    the National Natural Science Foundation of China, No. 81001703*

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Abstract:

BACKGROUND: Gastrointestinal bioadhesive controlled release tablets can extend the residence time of pharmaceutical preparations in gastrointestinal tract, and increase drug bioavailability.
OBJECTIVE: To prepare 5-fluorouracil gastrointestinal bioadhesive controlled release tablets.
METHODS: Taking biodegradable Zein as stent material and adhesive material, fluorouracil as model drug, the gastrointestinal controlled release tablets were prepared. The chip technology was orthogonally designed to optimize the choice of coating solution, the in vitro bioadhesion of controlled release tablets and the correlation of in vivo and in vitro were also been studied.
RESULTS AND CONCLUSION: The fluorouracil Zein bioadhesive tablets were in line with zero-grade release characteristic in vitro within 10 hours. The prepared gastrointestinal bioadhesive controlled release tablets have good adhesive properties. Moreover, the blood drug concentration in vivo within 2-8 hours was relatively stable, without obvious peak valley, and there was a good correlation of the release and absorption in vivo and in vitro.

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