Abstract:

BACKGROUND: Bone marrow mesenchymal stem cells (BMSCs) have great self-proliferative capacity and pluripotent differentiation, so it becomes a hot spot of the treatment of early avascular necrosis of the femoral head (ANFH).
OBJECTIVE: To summarize the bionomics of BMSCs and its effect and mechanism on the treatment of early ANFH.
METHODS: The literatures were related to the bionomics of BMSCs and its effect and mechanism on the treatment of early ANFH from PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) between January 1992 and October 2010, CNKI database (http://www.cnki.net/index.htm) between January 2000 and October 2010 were retrieved. The index words were “femur head necrosis, mesenchymal stem cell, cell culture, therapy, overview” both in English and in Chinese. Outdated and repetitive researches were excluded, and 30 literatures were included for summarization.
RESULTS AND CONCLUSION: Using osteogenic action and angiogenesis directly treated lesion location of ANFH, so as to achieve the purpose of the treatment of early ANFH, which is the hot spot of the treatment of early ANFH currently. In future, we should further analyze BMSCs in the potential and influential factor of proliferation and differentiation of ischemic ANFH, the prevention of restenosis, the time of bone defects repair and survival and differentiation factors of stem cells after BMSCs transplantation, such as local infection and eneral immunity, and whether stem cells can flow to other sites with the impact of the blood flow during interventional therapy, these problems are still to be further solved.