Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (9): 1603-1606.doi: 10.3969/j.issn.1673-8225.2011.09.020

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A systematic review of osteogenesis induced by recombinant human bone morphogenetic protein-2/absorbable collagen sponge for maxillary sinus floor augmentation

Ning Jing1, 2, Liu Ya-li1, Yang Ke-hu1, 3, Wang Lin2, Ma Peng2, Liu Bin2   

  1. 1Evidence-Based Medicine Center of Lanzhou University, Lanzhou  730000, Gansu Province, China
    2School of Stomatology, Lanzhou University, Lanzhou  730000, Gansu Province, China
    3First Hospital of Lanzhou University, Lanzhou  730000, Gansu Province, China
  • Received:2010-09-19 Revised:2011-01-12 Online:2011-02-26 Published:2011-02-26
  • Contact: Liu Bin, Doctor, Professor, School of Stomatology, Lanzhou University, Lanzhou 730000, Gansu Province, China liubkq@lzu.edu.cn
  • About author:Ning Jing★, Studying for master’s degree, Evidence-Based Medicine Center of Lanzhou University, Lanzhou 730000, Gansu Province, China; School of Stomatology, Lanzhou University, Lanzhou 730000, Gansu Province, China njmd2006@163.com
  • Supported by:

    Evidence-Based Medicine Center of Lanzhou University, “Evidence-Based Medicine Teaching Innovation Fund”, No. 2009LDEBM-A*; State Key Laboratory of Solid Lubrication Project, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, No. 0808*

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Abstract:

BACKGROUND: Maxillary antrum limits the application of implant in maxillary molar region; the application of guided bone regeneration (GBR) provides chance and security for the elevation maxillary sinus floor. Although pharmacology, animal experiment, and some clinical research have verified the osteoinductive of recombinant human bone morphogenetic protein-2/absorbable collagen sponge (rhBMP-2/ACS), the existence of the limitations of the study, cases of self-limiting, the reliability of the results is not very clear.
OBJECTIVE: To systematically evaluate curative effect and safety of rhBMP-2/ ACS on the incrementation of alveolar crest in process of maxillary sinus floor augmentation.
METHODS: A computer based online search of PubMed database (1996/2009-12), Embase database (1974/2009-12), Cochrane Library database (the 4th period, 2009), CBM database (1978/2009-12), and CNKI database (1994/2009-12), VIP database (1989/2009-12) was performed with the key words “rhBMP-2, ACS, autogenous bone graft” in English, and “rhBMP-2, ACS, autogenous bone graft” in Chinese. The literatures were retrieved by the way of free words combined with key words. The studies of randomized controlled trials (RCTs) which addressed the efficiency of rhBMP-2/ACS compared with an autogenous bone graft were selected and reviewed. And RevMan 5 software was used for Meta-analysis.
RESULTS AND CONCLUSION: Three RCTs was finally included, a total of 288 patients. Meta-analysis results showed that there was significant difference between 1.5 g/L rhBMP-2/ACS and autogenous bone graft in height changes and width changes of alveolar ridge. While for 0.75 g/L rhBMP-2/ACS group, there was no significant difference in height changes of alveolar ridge. There was significant difference in width changes of alveolar ridge. After 6 months rhBMP-2/ACS, the bone density can be improved in implant region, no reports of untoward reaction. 1.5 g/L rhBMP-2/ACS, 0.75 g/L rhBMP-2/ACS and autogenous bone graft had good effects for the bone induction, and the effect of rhBMP-2/ACS was superior to autogenous bone.

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