Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (9): 1541-1544.doi: 10.3969/j.issn.1673-8225.2011.09.006

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Relationship between pneumatic tourniquet application in total knee arthroplasty and hypercoagulability

Zhou Wei1, Liu Dong-hai1, Ma Guo-tao1, Gong Yue-kun2, Liu Jin-song2   

  1. 1Department of Orthopedics, First People’s Hospital of Pingdingshan, Pingdingshan  467000, Henan Province, China
    2Department of Orthopedics, First Affiliated Hospital of Kunming Medical University, Kunming  650031, Yunnan Province, China
  • Received:2010-08-26 Revised:2010-10-13 Online:2011-02-26 Published:2011-02-26
  • Contact: Gong Yue-kun, Doctor, Professor, Master’s supervisor, Department of Orthopedics, First Affiliated Hospital of Kunming Medical University, Kunming 650031, Yunnan Province, China
  • About author:Zhou Wei★, Master, Attending physician, Department of Orthopedics, First People’s Hospital of Pingdingshan, Pingdingshan 467000, Henan Province, China zhouwei666999@ sina.com
  • Supported by:

    the Joint Special Projects of Science and Technology Department of Yunnan Province, No. 2008CD015*

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Abstract:

BACKGROUND: Numerous studies show the pneumatic tourniquet on hemodynamics during total knee arthroplasty (TKA) can lead to hypercoagulability or deep vein thrombosis.
OBJECTIVE: To investigate correlation between tourniquet and hypercoagulability during TKA.
METHODS: The 39 cases undergoing TKA were randomly divided into two groups: tourniquet group (n=20) and non-tourniquet group (n=19). Hemorheology, D-dimer, fibrinogen degradation products (FDP) and antithrombin-Ⅲ (AT-Ⅲ) were measured pre-, 5 minutes after of the first tourniquet deflation in the tourniquet group and post-operation in the non-tourniquet group.
RESULTS AND CONCLUSION: The indexes of two groups had no differences before operation (P > 0.05). After operation, red blood cell deformability index TK and AT-Ⅲ were significantly reduced than that before surgery, while erythrocyte aggregation index, erythrocyte rigidity index, D-dimer and FDP were significantly greater than that before surgery (P < 0.05). Erythrocyte aggregation index, erythrocyte rigidity index, D-dimer and FDP were significantly increased, while red blood cell deformability index TK and AT-Ⅲ were significantly decreased in tourniquet group compared with non-tourniquet group (P < 0.05). Results show that trauma of TKA and the application of tourniquet during surgery can lead to hypercoagulable state. The use of pneumatic tourniquet during TKA exacerbated hypercoagulable state, which prone to deep venous thrombosis.

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