Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (46): 8612-.doi: 10.3969/j.issn.1673-8225.2010.46.015

Previous Articles     Next Articles

Angiogenesis of a nude mouse model with human endometriosis

Ma Ying, He Yuan-li   

  1. Department of Gynecology and Obstetrics, Zhujiang Hospital, Southern Medical University, Guangzhou  510282, Guangdong Province, China
  • Online:2010-11-12 Published:2010-11-12
  • Contact: He Yuan-li, Chief physician, Professor, Department of Gynecology and Obstetrics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, China heyuanli310@yaoo.com.cn
  • About author:Ma Ying☆, Doctor, Attending physician, Department of Gynecology and Obstetrics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, China xxbcxh@sohu.com

PDF

425

Abstract:

BACKGROUND: Many studies indicated that angiogenesis play an important role in formation and development of endometriosis. Antiangiogenesis may be a useful way to treat endometriosis.
OBJECTIVE: To establish a nude mouse model with human endometriosis, and to observe the angiogenesis in ectopic focus.
METHODS: The nude mouse endometriosis model was established by abdominal cavity injection with the endometria of endometriosis patients. The morphological features of ectopic focus were observed by a light microscope, and the expression of vascular endothelial growth factor and microvessel density were detected by immunohistochemistry.
RESULTS AND CONCLUSION: The ectopic lesions were observed endometrium-liked structure with gland and substance under a light microscope. The expression of vascular endothelial growth factor in the ectopic endometrium was greater than that of eutopic endometrium, and many microvessels formed. It is suggested that, the endometriosis nude mice model was successfully established. There are new born vessels in ectopic lesions.

CLC Number: