Abstract:

OBJECTIVE: To introduce clinical application of drug-eluting stent, and explore the safety and efficacy by analyzing stent, eluting material, and bioactive components.
METHODS: With key words “drug-eluting stent, bare metal stent, restenosis” in Chinese and English, a computer-based online search was performed for articles published between January 1990 and October 2008. Articles related to comparison of safety between drug-eluting stent and bare metal stent were included. Repetitive studies or Meta analysis were excluded. Finally, 17 articles were selected, which discussed safety and efficacy of drug-eluting stent in clinical application.
RESULTS: Currently used drug-eluting stent can be further improved to fit small vessels, furcation site and expanded PCI indications. Moreover, new coating and biomaterials, drug selection and eluting technique, methods to improve tunica intima healing at implant site are important.
CONCLUSION: Modification of stent platform and development of novel stent become study hot spot. Long-term effect is significant for application of drug-eluting stent.