Abstract:

BACKGROUND: As a new bone graft, nano-artificial bone has many good qualities such as good biocompatibility, but the clinical effect in treating bone tumors and bone disease needs more studies.
OBJECTIVE: To evaluate the clinical results of nano-artificial bone combined with autologous bone in treating bone tumors and bone disease.
METHODS: A total of 43 patients with bone tumors and bone disease were implanted with nano-artificial bone or particles mixed with autologous bone after deleting tumor tissue, with lacune filling as much as possible. Four cases with pathologic fracture received internal fixation, while other cases had an orthosis. The postoperative complications of the whole body and the operation region were observed, and the X-ray films were observed to evaluate the bone healing at different time.
RESULTS AND CONCLUSION: All 43 cases were followed up for average 6-24 months. Except one patient was delayed in wound healing, the other patients achieved good healing and general conditions. At 1-3 months postoperation, nano-artificial bone mixed with autologous bone graft began to fuse with bone tissue around defects, but increased density could be seen in local lesion. At 12 months, the bone graft region had a smilar density with the surronding bone tissues. The nano-artificial bone combined with autologous bone has been proved to be an ideal bone graft substitute material due to good results in the treatment of bone tumors and bone disease, and fewer complications. It has a good prospect of application.