Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (25): 4611-4613.doi: 10.3969/j.issn.1673-8225.2010.25.013

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Acute toxicity test of Ti6Al4V-AlTiN coating materials

Zhu Wei-dong1, Zhu Tao1, Wang Xu-dong2, Jiang Yao-guang3   

  1. 1 College of Materials and Metallurgy, Guizhou University, Guizhou Provincial Key Laboratory for Structure of Materials and Mechanical Behavior, Guiyang   550003, Guizhou Province, China; 2 Department of Physiology, Guiyang Medical University, Guiyang   550004, Guizhou Province, China; 3 Daping Hospital, Third Military Medical University of Chinese PLA, Chongqing   400042, China
  • Online:2010-06-18 Published:2010-06-18
  • About author:Zhu Wei-dong, Professor, College of Materials and Metallurgy, Guizhou University, Guizhou Provincial Key Laboratory for Structure of Materials and Mechanical Behavior, Guiyang 550003, Guizhou Province, China wdzhu@263.net
  • Supported by:

    Guizhou Provincial Science and Technology Project, No. 20082004*

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Abstract:

BACKGROUND: AlTiN ceramic coatings have many advantages such as high hardness, excellent wear properties, good chemical inertness and strong adhesion, which are all consistent with the characteristics of bio-ceramics. To achieve the clinical safety, a comprehensive evaluation of acute toxicity AlTiN coating is needed.
OBJECTIVE: To test acute toxicity of Ti6Al4V-AlTiN coating materials, and to provide a reference for long-term toxicity and other toxicological tests.
METHODS: The mouse left and right femoral quadriceps muscle was injected with aseptic Ti6Al4V-AlTiN coating material, the general condition and reaction on the injection site of animals were observed at 14 days after injection, normal saline served as the negative control.
RESULTS AND CONCLUSION: At 14 days after Ti6AI4V-AITiN injection into mouse quadriceps muscle on both sides, there was no significant difference in body mass growth between test sample group and negative control group. The animals showed normal diet, appearance, secretions, excretions, respiratory condition, central nervous system and limb activities, with no local congestion or swelling in the injection site, no animals died or showed poisoning.

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