Abstract:

OBJECTIVE: To evaluate the correlation of cardiovascular stent material with the inflammatory response.
METHODS: Using “coronary artery disease, coronary stent implantation, inflammation mediation, scaffold” in Chinese for the search terms, the Chinese Journal Full-text databases (CNKI: 2005/2009) and the Medline database (Pubmed: 1995/2008) were retrieved by computer. After excluding review articles, totally 45 articles were retrieved. According to the inclusion criteria, 32 articles selected by the author were involved in further analysis.
RESULTS: Rapamycin-eluting stents have excellent biocompatibility and low incidence of restenosis. It is an ideal material for cardiovascular stents. The clinical application of cardiovascular stent biocompatibility showed that drug-eluting stents in clinical application are not affected by age, sex and lesion site. Coated stents can be confirmed to reduce the inflammatory response and the incidence of restenosis after stent implantation, and have an advantage in reducing adverse cardiac events.
CONCLUSION: In addition to anti-proliferative properties, as compared with bare metal stents, drug-eluting stents have significant anti-inflammatory properties and then reduces the incidence of restenosis. Rapamycin-eluting stents is a good cardiovascular scaffold.