Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (3): 567-570.doi: 10.3969/j.issn.1673-8225.2010.03.046

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Preparation and properties of carboxymethyl chitosan calcium

Cai Wen-di1, Chu Jin-xin1, Han Bao-qin2, Wang Chang-hong2, Liu Wan-shun2   

  1. 1 Department of Basic Medical Teaching, Weifang Medical University, Weifang   261053, Shandong Province, China; 2 College of Marine Life Sciences, Ocean U niversity of China, Qingdao   266003, Shandong Province, China
  • Online:2010-01-15 Published:2010-01-15
  • Contact: Han Bao-qin, Professor, Master’s supervisor, College of Marine Life Sciences, Ocean University of China, Qingdao 266003, Shandong Province, China
  • About author:Cai Wen-di★, Master, Department of Basic Medical Teaching, Weifang Medical University, Weifang 261053, Shandong Province, China oceanwendy@163.com

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Abstract:

BACKGROUND: Carboxymethyl chitosan is a water-soluble derivate modified from chitosan, with various biological activities. It is a good ligand of metal ion and can integrate Ca 2+ to prepare a novel biological material. 
OBJECTIVE: To explore a method for preparing carboxymethyl chitosan calcium (CCC) and analyze its properties and structure.
METHODS: CCC was produced by carboxymethyl chitosan reacting with solution of calcium chloride. The solubility, carboxymethylation degree, rotational viscosity, and calcium content of CCC were determined, and infrared and ultraviolet spectral analyses were performed.
RESULTS AND CONCLUSION: The calcium content of CCC was approximately 15%. Compared with carboxymethyl chitosan, infrared spectrum and ultraviolet spectrum of CCC were changed. The prepared CCC is a new calcium compound through property and structural analysis.

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