Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (3): 549-551.doi: 10.3969/j.issn.1673-8225.2010.03.041

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Physio-chemical progress and clinical application of microencapsulated hepatocytes

Wang Jia-xiang, Han Bao-san, Wu Xu-bo, Yu Song-lin, Huang Fang, Kuang Jie, Peng Cheng-hong   

  1. Ruijin Hospital, Shanghai Jiao Tong University Medical School, Shanghai   200025, China
  • Online:2010-01-15 Published:2010-01-15
  • Contact: Peng Cheng-hong, Doctor, Professor, Ruijin Hospital, Shanghai Jiao Tong University Medical School, Shanghai 200025, China chhpeng@188.com
  • About author:Wang Jia-xiang★, Studying for master’s degree, Ruijin Hospital, Shanghai Jiao Tong University Medical School, Shanghai 200025, China 13564064276@139.com
  • Supported by:

     the National High-Tech Research and Development Program (863 Program) in the Eleventh Five-Year Plan, No. 2008AA02Z417*; the Natural Science Foundation of the Science and Technology Commission of Shanghai Municipality, No. 07ZR14076*; the Key Program of National Natural Science Foundation of China, No. 20434030*; the National Natural Science Foundation of China, No. 30672043*, 30772105*, 20074031*, 30801107*; Innovation Program of Shanghai Municipal Education Commission, No. 09YZ84*

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Abstract:

With the development of cell separation technique, hepatocyte transplantation becomes a hot topic; however, the application is limited by donor deficiency and immunological rejection. Microencapsulated hepatocytes contribute to the promotion and application for liver cell transplantation, for which provide a large amount of high activity and good function of liver cells. In this paper, liver cell microencapsulation technology and its progress in applications were reviewed, providing prospective way for large-scale and high-active culture in vitro and long-term cryopreservation.

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