Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (2): 365-369.doi: 10.3969/j.issn.1673-8225.2010.02.041

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From Minu3D cultural system to aldosterone-induced tubulogenesis

Hu Kang-hong   

  1. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, Hubei Province, China
  • Online:2010-01-08 Published:2010-01-08
  • About author:Hu Kang-hong☆, Ph.D., Professor, Supervisor for Ph.D. candidates, Principle investigator, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, Hubei Province, China hukgh@wh.iov.cn
  • Supported by:

    the Program of Chinese Academy of Sciences, No. 0802021SA1*; the National Key Projects of China, No. 2008ZX10002-011*, 2008ZX10004-004*

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Abstract:

The existing technical disadvantages of culture systems so far developed have limited the molecular biological study of tubulogenesis. Recently, a newly developed Minu3D system creates controllable growth conditions and allows the generation of tubules from renal stem/progenitor cells. It is for the first time indicated that aldosterone is able to induce the formation of tubules. Aldosterone may trigger some of mineralocorticoid receptor-mediated signaling pathways for the initiation and the regulation of the tubulogenesis. The implication of these studies toward unveiling tubulogenesis is discussed.

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