Chinese Journal of Tissue Engineering Research ›› 2026, Vol. 30 ›› Issue (33): 8811-8821.doi: 10.12307/2026.392
Previous Articles Next Articles
Effects of exercise intensity on cognitive function in different age groups: a meta-analysis
Li Bing1, Su Yu1, Quan Jialin2, Yuan Yufeng1, Wang Quanjun1, Xie Ke1, Wang Ping'an1, Yu Songyuan1
- 1Physical Fitness and Health Studio, College of Physical Education, Shaoguan University, Shaoguan 512005, Guangdong Province, China; 2Graduate School of Guangzhou Sport University, Guangzhou 510500, Guangdong Province China
-
Received:2024-07-09Revised:2025-10-22Online:2026-11-28Published:2026-06-18 -
Contact:Su Yu, PhD, Professor, Physical Fitness and Health Studio, College of Physical Education, Shaoguan University, Shaoguan 512005, Guangdong Province, China Co-corresponding author: Quan Jialin, MS, Graduate School of Guangzhou Sport University, Guangzhou 510500, Guangdong Province China -
About author:Li Bing, MS, Physical Fitness and Health Studio, College of Physical Education, Shaoguan University, Shaoguan 512005, Guangdong Province, China -
Supported by:Guangdong Provincial Philosophy and Social Sciences Planning Project, No. GD20YDXZTY27 (to SY); Shaoguan Municipal Philosophy and Social Sciences Planning Special Commissioned Project on Basic Education, No. W2022018 (to SY); Shaoguan Municipal Philosophy and Social Sciences Planning Project, No. G2022018 (to LB)
CLC Number:
Cite this article
Li Bing, Su Yu, Quan Jialin, Yuan Yufeng, Wang Quanjun, Xie Ke, Wang Ping'an, Yu Songyuan. Effects of exercise intensity on cognitive function in different age groups: a meta-analysis[J]. Chinese Journal of Tissue Engineering Research, 2026, 30(33): 8811-8821.
share this article
Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks
2.1 文献筛选流程以及结果 检索了中国知网(2 375篇)、Cochrane Library (1 298篇)、PubMed(1 704篇)、Web of Science(850篇)、Embase(3 191篇)5个数据库。利用文献管理软件剔重，阅读标题、摘要以及全文，排除不符合要求文章后，最终纳入63篇文献进行网状Meta分析(图1)。 2.2 纳入文献的基本特征 纳入63篇文献[34-96]，共包括4 167名受试者，男女不限，所有受试者均按照随机原则进行分组。年龄范围为5-83岁。结局指标方面，21项研究报告整体认知[34-36，38，42-44，49-50，55，57，61，63，66-67，73，75，81，85-86，88]，35项研究报告记忆表现[34，36-37，39，41-42，45-49，51，53-54，56，58-60，62，64，68-71，73，76-78，82，88-89，91-94]，34项研究报告抑制控制[36，39-42，45-49，53-54，58，64-65，68，70，72，74-75，77，79-80，82-84，87-90，92，94-96]，22项研"
2.3 纳入文献的研究偏倚风险评价结果 采用ROB2风险偏倚评估工具对纳入的63项研究进行偏倚风险评价。在随机序列方法方面，3项研究并未具体描述随机序列方法[38，41，67]，其余研究都描述了产生随机分配序列方法，为低风险偏倚。35项研究具体描述了预期干预措施[34-36，39-40，45，51-52，56，59-61，63-65，69-71，73，75-77，79，81-83，85-88，90，92-93，95-96]，偏倚风险较低，15项研究信息模糊[37，41-44，46-48，53-54，58，62，72，78，80]，被定义为一般风险偏倚，13项研究未描述预期干预措施[38，49-50，55，57，66-68，74，84，89，91，94]，被定义为高风险偏倚。在数据完整性方面，2项研究数据不完整[54，66]，其余研究都为低风险偏倚。在结局测量的偏倚方面，23项研究为一般风险[34，40-41，46，49-50，52，57-58，62-66，69，72，74，77，81-82，84，92，95]，8项研究为高风险[36，38-39，54-55，67，80，94]，其余均为低风险。在选择报告偏倚方面，5项研究为一般风险[39，48，54，71，77]，其余均为低风险。在总体偏倚上，21项研究为低风险，16项研究为一般风险，26项研究为高风险(图2)。 2.4 Meta分析网络关系结果 共纳入63项研究进行分析，包含4个认知相关的结局指标，分别为整体认知、认知灵活性、记忆表现、抑制控制。由图3可见，整体认知网状关系图显示，对照组、低强度运动组、中等强度运动组和高强度运动组形成了5个闭合环。认知灵活性网状关系图显示，年龄≤18岁群体不成网状，年龄> 18岁人群中4种强度间形成3个闭合环。记忆表现网状关系图显示，年龄< 18岁人群中对照组、低强度运动、高强度运动3种强度间形成1个闭合环，年龄≤45岁人群4种强度间形成2个闭合环，年龄> 45岁人群则形成5个闭合环。抑制控制网状关系图显示，年龄< 18岁人群中4种强度间形成2个闭合环，年龄≤45岁人群形成4个闭合环，年龄> 45岁人群形成2个闭合环。 2.5 网状Meta分析结果 2.5.1 整体认知 由图4可见，对于年龄> 45岁人群，与对照组相比，中等强度运动(SMD=1.34，95%CI= 0.83-1.85，P < 0.05)和高强度运动(SMD=1.30，95%CI=0.29-2.33，P < 0.05)能显著提高整体认知水平。通过效应值发现，中等强度运动的影响优于高强度运动。各运动强度间的两两比较不存在显著性差异(P > 0.05)。SUCAR值概率排序从高到低为：中等强度运动(SUCAR=0.86)、高强度运动(SUCAR=0.83)、低强度运动(SUCAR=0.53)、对照组(SUCAR=0.26)。 2.5.2 记忆表现 由图5可见，对于年龄< 18岁人群，与对照组相比，中等强度运动(SMD=0.68，95%CI=0.29-1.09，P < 0.05)显著提高记忆表现水平。SUCAR值概率排序从高到低为：中等强度运动(SUCAR=0.76)、高强度运动(SUCAR=0.73)、低强度运动(SUCAR=0.64)、对照组(SUCAR=0.32)。 由图5可见，对于年龄≤45岁人群，与对照组相比，中等强度运动(SMD=0.60，95%CI=0.33-0.89，P < 0.05)能显著提高记忆表现水平。各运动强度间两两比较不存在显著性差异(P > 0.05)。SUCAR值概率排序从高到低为：中等强度运动(SUCAR=0.81)、高强度运动(SUCAR=0.71)、低强度运动(SUCAR=0.70) 、对照组(SUCAR=0.27)。 由图5可见，对于年龄> 45岁人群，与对照组相比，高强度运动(SMD=0.40，95%CI=0.06-0.75，P < 0.05)能显著提高记忆表现水平。各运动强度间两两比较不存在显著性差异(P > 0.05)。SUCAR值概率排序从高到低为：高强度运动(SUCAR=0.90)、中等强度运动(SUCAR=0.72)、低强度运动(SUCAR=0.58)、对照组(SUCAR= 0.29)。 2.5.3 抑制控制结果 由图6可见，对于年龄< 18岁人群，与对照组相比，中等强度运动(SMD=0.56，95%CI= 0.31-0.81，P < 0.05)和高强度运动(SMD=0.43，95%CI=0.05-0.83，P < 0.05)能显著提高抑制控制水平。各运动强度间两两比较不存在显著性差异(P > 0.05)。SUCAR值概率排序从高到低为：中等强度运动(SUCAR=0.92)、高强度运动(SUCAR=0.79)、低强度运动(SUCAR=0.44)、对照组(SUCAR=0.32)。"
"
"
"
由图6可见，对于年龄≤45岁人群，与对照组相比，中等强度运动(SMD=0.55，95%CI=0.35-0.77，P < 0.05)和高强度运动(SMD=0.51，95%CI=0.19-0.85，P < 0.05)能显著提高抑制控制水平。各运动强度间两两比较不存在显著性差异(P > 0.05)。SUCAR值概率排序从高到低为：中等强度运动(SUCAR=0.89)、高强度运动(SUCAR=0.83)、低强度运动(SUCAR=0.49)、对照组(SUCAR=0.27)。 由图6可见，对于年龄> 45岁人群，与对照组相比，3种运动强度均不存在显著影响(P > 0.05)。各运动强度间两两比较同样不存在显著性差异(P > 0.05)。SUCAR值概率排序从高到低为：中等强度运动(SUCAR=0.76)、低强度运动(SUCAR=0.69)、高强度运动(SUCAR=0.55)、对照组(SUCAR= 0.47)。 2.5.4 认知灵活性结果 由图7可见，对于年龄≤18岁人群，与对照组相比，中等强度运动(SMD=0.62，95%CI=0.25-1.01，P < 0.05)能显著提高认知灵活性水平。各运动强度间两两比较不存在显著性差异(P > 0.05)。SUCAR值概率排序从高到低为：高强度运动(SUCAR=0.87)、中等强度运动(SUCAR=0.77)、对照组(SUCAR=0.35)。 由图7可见，对于年龄> 18岁人群，与对照组相比，中等强度运动(SMD=0.47，95%CI=0.01-1.03，P < 0.05)能显著提高认知灵活性水平。各运动强度间两两比较不存在显著性差异(P > 0.05)。SUCAR值概率排序从高到低为：中等强度运动(SUCAR=0.92)、低强度运动(SUCAR=0.59)、高强度运动(SUCAR=0.55)、对照组(SUCAR= 0.42)。 2.6 回归分析 由表2可见，年龄对于整体认知、记忆表现、抑制控制和认知灵活性的干预效果不存在显著的调节作用。认知状态(认知障碍和认知健康)对整体认知、记忆表现、抑制控制和认知灵活性的干预效果同样不存在显著的调节作用。 2.7 一致性检验、收敛诊断、发表偏倚分析和敏感性分析结果 计算偏差信息准则值来判断模型拟合优度，结果发现一致性模型的偏差信息准则值与不一致性模型没有显著差异，提示纳入研究不存在明显的全局不一致性，使用一致性模型来分析数据是合理的。同时采用节点劈裂法对纳入的研究进行不一致性检验，检验各运动强度组与对照组之间的直接比较与间接比较是否具有一致性，结果发现，所有比较均P > 0.05，表明纳入研究具有较好的一致性，适合采用一致性模型进行数据分析。由于年龄≤18岁群体认知灵活性的网状关系图未成环，故不进行一致性检验。 在一致性模型中各结局指标密度图的Bandwidth值均趋向于0，PSRF均趋向1，表明模型的收敛效能较好，结果可靠。对所有纳入的研究进行发表偏倚分析发现，整体认知(t=-2.28，P < 0.05)以及< 18岁人群(t=-3.16，P < 0.05)和< 45岁人群(t=-2.96，P < 0.05)的记忆表现相关研究存在一定的发表偏倚，在其他研究中均未发现显著性的发表偏倚(P > 0.05)。研究采用两种相关系数(r=0.5，r=0.8)"
"
和两种先验分布(极弱信息先验、弱信息先验)来进行敏感性分析，所得结论均保持一致。 一致性检验图和漏斗图见图8-16。敏感性分析结果见表3-5。"
"
"
"
"
"
| [1] Risk Reduction of Cognitive Decline and Dementia: WHO Guidelines. Geneva: World Health Organization, 2019. [2] BIDZAN-BLUMA I, LIPOWSKA M. Physical Activity and Cognitive Functioning of Children: A Systematic Review. Int J Environ Res Public Health. 2018;15(4):800. [3] EVANS JJ. Basic concepts and principles of neuropsychological assessment//HALLIGAN PW, KISCHKA U, MARSHALL JC. Handbook of Clinical Neuropsychology. Oxford, UK:University Press, 2003:15-26. [4] 2023 Alzheimer’s disease facts and figures. Alzheimers Dement. 2023;19(4):1598-1695. [5] WORLD HEALTH ORGANIZATION (2022). Global status report on the public health response to dementia. https://www.who.int/publications/i/item/9789240033245 [6] LIVINGSTON G, HUNTLEY J, SOMMERLAD A, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396(10248):413-446. [7] IZQUIERDO M, DUQUE G, MORLEY JE. Physical activity guidelines for older people: knowledge gaps and future directions. Lancet Healthy Longev. 2021;2(6):e380-e383. [8] ZHANG M, JIA J, YANG Y, et al. Effects of exercise interventions on cognitive functions in healthy populations: A systematic review and meta-analysis. Ageing Res Rev. 2023;92:102116. [9] DE SOUSA FERNANDES MS, ORDÔNIO TF, SANTOS GCJ, et al. Effects of Physical Exercise on Neuroplasticity and Brain Function: A Systematic Review in Human and Animal Studies. Neural Plast. 2020; 2020:8856621. [10] BULL FC, AL-ANSARI SS, BIDDLE S, et al. World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br J Sports Med. 2020;54(24):1451-1462. [11] CHAN YS, JANG JT, HO CS. Effects of physical exercise on children with attention deficit hyperactivity disorder. Biomed J. 2022;45(2):265-270. [12] STRAIN T, FLAXMAN S, GUTHOLD R, et al. National, regional, and global trends in insufficient physical activity among adults from 2000 to 2022: a pooled analysis of 507 population-based surveys with 5·7 million participants. Lancet Glob Health. 2024;12(8):e1232-e1243. [13] CONTRERAS-OSORIO F, RAMIREZ-CAMPILLO R, CERDA-VEGA E, et al. Effects of Physical Exercise on Executive Function in Adults with Depression: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2022;19(22):15270. [14] XU L, GU H, CAI X, et al. The Effects of Exercise for Cognitive Function in Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Int J Environ Res Public Health. 2023;20(2):1088. [15] CHEN HY, HUNG CS, WU TT, et al. The Combined Impact of Physical Activity and Sedentary Behavior on Executive Functions in Older Adults: A Cross-Sectional Study. Psychol Res Behav Manag. 2024; 17:3851-3861. [16] PIERCY KL, TROIANO RP, BALLARD RM, et al. The Physical Activity Guidelines for Americans. JAMA. 2018;320(19):2020-2028. [17] HUANG X, ZHAO X, LI B, et al. Comparative efficacy of various exercise interventions on cognitive function in patients with mild cognitive impairment or dementia: A systematic review and network meta-analysis. J Sport Health Sci. 2022;11(2):212-223. [18] DEMURTAS J, SCHOENE D, TORBAHN G, et al. Physical Activity and Exercise in Mild Cognitive Impairment and Dementia: An Umbrella Review of Intervention and Observational Studies. J Am Med Dir Assoc. 2020;21(10):1415-1422.e6. [19] LÓPEZ-ORTIZ S, VALENZUELA PL, SEISDEDOS MM, et al. Exercise interventions in Alzheimer’s disease: A systematic review and meta-analysis of randomized controlled trials. Ageing Res Rev. 2021;72:101479. [20] GALLARDO-GÓMEZ D, DEL POZO-CRUZ J, NOETEL M, et al. Optimal dose and type of exercise to improve cognitive function in older adults: A systematic review and bayesian model-based network meta-analysis of RCTs. Ageing Res Rev. 2022;76:101591. [21] ZHU F, ZHU X, BI X, et al. Comparative effectiveness of various physical exercise interventions on executive functions and related symptoms in children and adolescents with attention deficit hyperactivity disorder: A systematic review and network meta-analysis. Front Public Health. 2023; 11:1133727. [22] KIM R, LEE TL, LEE H, et al. Effects of physical exercise interventions on cognitive function in Parkinson’s disease: An updated systematic review and meta-analysis of randomized controlled trials. Parkinsonism Relat Disord. 2023;117:105908. [23] LIANG X, LI R, WONG SHS, et al. The Effects of Exercise Interventions on Executive Functions in Children and Adolescents with Autism Spectrum Disorder: A Systematic Review and Meta-analysis. Sports Med. 2022;52(1):75-88. [24] HUANG Y, OU H, ZHAO W, et al. The effects of moderate-intensity aerobic exercise on cognitive function in individuals with stroke-induced mild cognitive impairment: a randomized controlled pilot study. J Rehabil Med. 2024;56:jrm33001. [25] COSTIGAN SA, EATHER N, PLOTNIKOFF RC, et al. High-Intensity Interval Training for Cognitive and Mental Health in Adolescents. Med Sci Sports Exerc. 2016;48(10):1985-1993. [26] LAMB SE, SHEEHAN B, ATHERTON N, et al. Dementia And Physical Activity (DAPA) trial of moderate to high intensity exercise training for people with dementia: randomised controlled trial. BMJ. 2018;361:k1675. [27] ANSAI JH, AURICHIO TR, GONÇALVES R, et al. Effects of two physical exercise protocols on physical performance related to falls in the oldest old: A randomized controlled trial. Geriatr Gerontol Int. 2016;16(4):492-499. [28] RICO-GONZÁLEZ M, GONZÁLEZ-DEVESA D, GÓMEZ-CARMONA CD, et al. Exercise as Modulator of Brain-Derived Neurotrophic Factor in Adolescents: A Systematic Review of Randomized Controlled Trials. Sports (Basel). 2025;13(8):253. [29] PAGE MJ, MCKENZIE JE, BOSSUYT PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. [30] CUMPSTON M, LI T, PAGE MJ, et al. Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions. Cochrane Database Syst Rev. 2019;10(10):ED000142. [31] YIN M, DENG S, DENG J, et al. Physiological adaptations and performance enhancement with combined blood flow restricted and interval training: A systematic review with meta-analysis. J Sport Health Sci. 2025;14:101030. [32] CUMPSTON MS, MCKENZIE JE, WELCH VA, et al. Strengthening systematic reviews in public health: guidance in the Cochrane Handbook for Systematic Reviews of Interventions, 2nd edition. J Public Health (Oxf). 2022;44(4):e588-e592. [33] 张天嵩.Stata软件network组命令在网状meta分析中的应用[J].中国循证医学杂志,2015, 15(11):1352-1356. [34] LAUTENSCHLAGER NT, COX KL, FLICKER L, et al. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. JAMA. 2008;300(9):1027-1037. [35] HÖTTING K, REICH B, HOLZSCHNEIDER K, et al. Differential cognitive effects of cycling versus stretching/coordination training in middle-aged adults. Health Psychol. 2012;31(2):145-155. [36] SUZUKI T, SHIMADA H, MAKIZAKO H, et al. Effects of multicomponent exercise on cognitive function in older adults with amnestic mild cognitive impairment: a randomized controlled trial. BMC Neurol. 2012;12:128. [37] NAGAMATSU LS, CHAN A, DAVIS JC, et al. Physical activity improves verbal and spatial memory in older adults with probable mild cognitive impairment: a 6-month randomized controlled trial. J Aging Res. 2013;2013:861893. [38] 王英,沈飞飞,朱奕,等.中高强度有氧运动干预阿尔茨海默病的临床研究[J].中国临床神经科学,2014,22(5):504-509. [39] NOUCHI R, TAKI Y, TAKEUCHI H, et al. Four weeks of combination exercise training improved executive functions, episodic memory, and processing speed in healthy elderly people: evidence from a randomized controlled trial. Age (Dordr). 2014;36(2):787-799. [40] KRAFFT CE, SCHWARZ NF, CHI L, et al. An 8-month randomized controlled exercise trial alters brain activation during cognitive tasks in overweight children. Obesity (Silver Spring). 2014;22(1):232-242. [41] 陈爱国,蒋任薇,吉晓海,等.8周中等强度的花样跳绳运动对聋哑儿童执行功能的影响[J].体育与科学,2015,36(4):105-109. [42] 江大雷,曾从周.8周中等强度足球运动游戏对学龄前儿童执行功能发展的影响[J].中国体育科技,2015,51(2):43-50. [43] 王晨宇.3个月有氧训练改善老年高血压患者血流动力学、运动能力和认知功能研究[J].沈阳体育学院学报,2015,34(6): 91-96. [44] ANSAI JH, REBELATTO JR. Effect of two physical exercise protocols on cognition and depressive symptoms in oldest-old people: A randomized controlled trial. Geriatr Gerontol Int. 2015;15(9):1127-1134. [45] SCHMIDT M, JÄGER K, EGGER F, et al. Cognitively Engaging Chronic Physical Activity, But Not Aerobic Exercise, Affects Executive Functions in Primary School Children: A Group-Randomized Controlled Trial. J Sport Exerc Psychol. 2015;37(6):575-591. [46] LIN J, CHAN SK, LEE EH, et al. Aerobic exercise and yoga improve neurocognitive function in women with early psychosis. NPJ Schizophr. 2015; 1(0):15047. [47] 陈爱国,朱丽娜,金柳,等.运动干预对聋哑儿童执行控制及其脑网络功能连接的影响[J].体育与科学,2016,37(6):94-101. [48] 潘家礼,殷恒婵,陈爱国,等.运动干预对学习困难、正常小学生执行功能影响的实验研究[J].体育科学,2016,36(6):84-91+97. [49] ALBINET CT, ABOU-DEST A, ANDRÉ N, et al. Executive functions improvement following a 5-month aquaerobics program in older adults: Role of cardiac vagal control in inhibition performance. Biol Psychol. 2016;115:69-77. [50] ALGHADIR AH, GABR SA, AL-EISA ES. Effects of Moderate Aerobic Exercise on Cognitive Abilities and Redox State Biomarkers in Older Adults. Oxid Med Cell Longev. 2016;2016:2545168. [51] LIU-AMBROSE T, BEST JR, DAVIS JC, et al. Aerobic exercise and vascular cognitive impairment: A randomized controlled trial. Neurology. 2016; 87(20):2082-2090. [52] CHEN SR, TSENG CL, KUO SY, et al. Effects of a physical activity intervention on autonomic and executive functions in obese young adolescents: A randomized controlled trial. Health Psychol. 2016;35(10):1120-1125. [53] 陈爱国,陈丽萍,颜军.8周足球运动改善留守儿童执行功能的实验研究[J].山东体育学院学报,2017,33(1):85-89. [54] MOREAU D, KIRK IJ, WALDIE KE. High-intensity training enhances executive function in children in a randomized, placebo-controlled trial. Elife. 2017;6:e25062. [55] YOON DH, KANG D, KIM HJ, et al. Effect of elastic band-based high-speed power training on cognitive function, physical performance and muscle strength in older women with mild cognitive impairment. Geriatr Gerontol Int. 2017; 17(5):765-772. [56] IULIANO E, FIORILLI G, AQUINO G, et al. Twelve-Week Exercise Influences Memory Complaint but not Memory Performance in Older Adults: A Randomized Controlled Study. J Aging Phys Act. 2017;25(4):612-620. [57] JONASSON LS, NYBERG L, KRAMER AF, et al. Aerobic Exercise Intervention, Cognitive Performance, and Brain Structure: Results from the Physical Influences on Brain in Aging (PHIBRA) Study. Front Aging Neurosci. 2017;8:336. [58] 陈爱国,熊轩,朱丽娜,等.运动干预对聋哑儿童执行功能及脑灰质体积的影响[J].体育科学,2018,38(1):42-48. [59] BAQUET L, HASSELMANN H, PATRA S, et al. Short-term interval aerobic exercise training does not improve memory functioning in relapsing-remitting multiple sclerosis-a randomized controlled trial. PeerJ. 2018;6:e6037. [60] LUDYGA S, GERBER M, KAMIJO K, et al. The effects of a school-based exercise program on neurophysiological indices of working memory operations in adolescents. J Sci Med Sport. 2018; 21(8):833-838. [61] SONG D, YU DSF. Effects of a moderate-intensity aerobic exercise programme on the cognitive function and quality of life of community-dwelling elderly people with mild cognitive impairment: A randomised controlled trial. Int J Nurs Stud. 2019;93:97-105. [62] ALLENDORFER JB, BROKAMP GA, NENERT R, et al. A pilot study of combined endurance and resistance exercise rehabilitation for verbal memory and functional connectivity improvement in epilepsy. Epilepsy Behav. 2019;96:44-56. [63] BADEMLI K, LOK N, CANBAZ M, et al. Effects of Physical Activity Program on cognitive function and sleep quality in elderly with mild cognitive impairment: A randomized controlled trial. Perspect Psychiatr Care. 2019;55(3):401-408. [64] BO W, LEI M, TAO S, et al. Effects of combined intervention of physical exercise and cognitive training on cognitive function in stroke survivors with vascular cognitive impairment: a randomized controlled trial. Clin Rehabil. 2019;33(1):54-63. [65] CHOU CC, CHEN KC, HUANG MY, et al. Can movement games enhance executive function in overweight children? A randomized controlled trial. J Teach Phys Educ. 2019;39(4):527-535. [66] HUANG N, LI W, RONG X, et al. Effects of a Modified Tai Chi Program on Older People with Mild Dementia: A Randomized Controlled Trial. J Alzheimers Dis. 2019;72(3):947-956. [67] 陈啸,丁兆生,张嘉玮,等.有氧运动干预对老年稳定性冠心病患者认知功能损伤改善作用[J].中国循证心血管医学杂志,2020,12(9):1084-1086. [68] 戴朝.足球锻炼及停练对10～11岁儿童执行功能的影响[J].成都体育学院学报,2020, 46(5):109-113. [69] 赵梅玲.两种训练干预方案对学龄前儿童体质与不同认知任务的影响[J].北京体育大学学报, 2020,43(5):89-97. [70] IMBODEN C, GERBER M, BECK J, et al. Aerobic exercise or stretching as add-on to inpatient treatment of depression: Similar antidepressant effects on depressive symptoms and larger effects on working memory for aerobic exercise alone. J Affect Disord. 2020;276:866-876. [71] MASSA N, ALROHAIBANI A, MAMMINO K, et al. The Effect of Aerobic Exercise on Physical and Cognitive Outcomes in a Small Cohort of Outpatients with Schizophrenia. Brain Plast. 2020;5(2):161-174. [72] MEKARI S, EARLE M, MARTINS R, et al. Effect of High Intensity Interval Training Compared to Continuous Training on Cognitive Performance in Young Healthy Adults: A Pilot Study. Brain Sci. 2020;10(2):81. [73] SANDERS LMJ, HORTOBÁGYI T, KARSSEMEIJER EGA, et al. Effects of low- and high-intensity physical exercise on physical and cognitive function in older persons with dementia: a randomized controlled trial. Alzheimers Res Ther. 2020;12(1):28. [74] ADCOCK M, FANKHAUSER M, POST J, et al. Effects of an In-home Multicomponent Exergame Training on Physical Functions, Cognition, and Brain Volume of Older Adults: A Randomized Controlled Trial. Front Med (Lausanne). 2020;6:321. [75] ENETTE L, VOGEL T, MERLE S, et al. Effect of 9 weeks continuous vs. interval aerobic training on plasma BDNF levels, aerobic fitness, cognitive capacity and quality of life among seniors with mild to moderate Alzheimer’s disease: a randomized controlled trial. Eur Rev Aging Phys Act. 2020;17:2. [76] LI M, FANG J, GAO Y, et al. Baduanjin mind-body exercise improves logical memory in long-term hospitalized patients with schizophrenia: A randomized controlled trial. Asian J Psychiatr. 2020;51:102046. [77] FROST NJ, WEINBORN M, GIGNAC GE, et al. A Randomized Controlled Trial of High-Intensity Exercise and Executive Functioning in Cognitively Normal Older Adults. Am J Geriatr Psychiatry. 2021; 29(2):129-140. [78] CARTA MG, COSSU G, PINTUS E, et al. Moderate Exercise Improves Cognitive Function in Healthy Elderly People: Results of a Randomized Controlled Trial. Clin Pract Epidemiol Ment Health. 2021;17:75-80. [79] ZHU L, YU Q, HEROLD F, et al. Brain Structure, Cardiorespiratory Fitness, and Executive Control Changes after a 9-Week Exercise Intervention in Young Adults: A Randomized Controlled Trial. Life (Basel). 2021;11(4):292. [80] MARTIN-WILLETT R, MORRIS B, WILCOX R, et al. The influence of a 16-week exercise program, APOE status, and age on executive function task performance: A randomized trial. Exp Gerontol. 2021;152:111431. [81] LI L, LIU M, ZENG H, et al. Multi-component exercise training improves the physical and cognitive function of the elderly with mild cognitive impairment: a six-month randomized controlled trial. Ann Palliat Med. 2021;10(8): 8919-8929. [82] LIU J, CHEN C, LIU M, et al. Effects of Aerobic Exercise on Cognitive Function in Women With Methamphetamine Dependence in a Detoxification Program in Tianjin, China: A Randomized Controlled Trial. J Nurs Res. 2021; 29(4):e164. [83] LOGAN NE, RAINE LB, DROLLETTE ES, et al. The differential relationship of an afterschool physical activity intervention on brain function and cognition in children with obesity and their normal weight peers. Pediatr Obes. 2021;16(2):e12708. [84] AMORIM OLIVEIRA GT, ELSANGEDY HM, PEREIRA DC, et al. Effects of 12 weeks of high-intensity interval, moderate-intensity continuous and self-selected intensity exercise training protocols on cognitive inhibitory control in overweight/obese adults: A randomized trial. Eur J Sport Sci. 2022;22(11):1724-1733. [85] DEIJLE IA, HEMMES R, BOSS HM, et al. Effect of an exercise intervention on global cognition after transient ischemic attack or minor stroke: the MoveIT randomized controlled trial. BMC Neurol. 2022;22(1):289. [86] KUREBAYASHI Y, MORI K, OTAKI J. Effects of mild-intensity physical exercise on neurocognition in inpatients with schizophrenia: A pilot randomized controlled trial. Perspect Psychiatr Care. 2022; 58(3):1037-1047. [87] ORTEGA FB, MORA-GONZALEZ J, CADENAS-SANCHEZ C, et al. Effects of an Exercise Program on Brain Health Outcomes for Children With Overweight or Obesity: The ActiveBrains Randomized Clinical Trial. JAMA Netw Open. 2022;5(8):e2227893. [88] YU AP, CHIN EC, YU DJ, et al. Tai Chi versus conventional exercise for improving cognitive function in older adults: a pilot randomized controlled trial. Sci Rep. 2022;12(1):8868. [89] 刘智妹,蔡可龙,朱丽娜,等.运动干预对孤独症伴有智力低下儿童执行功能及默认网络功能连接的影响[J].首都体育学院学报,2023, 35(5):493-502. [90] CHOU CC, KAO SC, PAN CC, et al. Cognitively engaging movement games improve interference control and academic performance in overweight children: A randomized control trial. Scand J Med Sci Sports. 2023;33(4):521-534. [91] WANG L, GUO F, ZHAO C, et al. The effect of aerobic dancing on physical fitness and cognitive function in older adults during the COVID-19 pandemic-a natural experiment. Sports Med Health Sci. 2023;5(3):196-204. [92] 毕存箭,尹小俭,施利娟,等.中高强度课堂体育锻炼对藏族初一年级学生心肺耐力和执行功能的干预效果[J].中国学校卫生,2024,45(3):322-325. [93] 蔡治东,江婉婷,王兴.弹力带抗阻运动对高龄老年人工作记忆的影响：来自fNIRS的证据[J].上海体育大学学报,2024,48(3):65-74. [94] 李良,黄孜耘,杨益成,等.球类身体活动干预对注意缺陷多动障碍儿童基本动作技能和执行功能的效果[J].中国康复理论与实践,2024, 30(4):479-486. [95] BYUN K, HYODO K, SUWABE K, et al. Mild exercise improves executive function with increasing neural efficiency in the prefrontal cortex of older adults. Geroscience. 2024;46(1):309-325. [96] GEJL AK, BUGGE A, ERNST MT, et al. Effects of 9 Weeks of High- or Moderate-Intensity Training on Cardiorespiratory Fitness, Inhibitory Control, and Plasma Brain-Derived Neurotrophic Factor in Danish Adolescents-A Randomized Controlled Trial. Scand J Med Sci Sports. 2024;34(8):e14703. [97] BIAZUS-SEHN LF, SCHUCH FB, FIRTH J, et al. Effects of physical exercise on cognitive function of older adults with mild cognitive impairment: A systematic review and meta-analysis. Arch Gerontol Geriatr. 2020;89:104048. [98] YANG J, DONG Y, YAN S, et al. Which Specific Exercise Models Are Most Effective on Global Cognition in Patients with Cognitive Impairment? A Network Meta-Analysis. Int J Environ Res Public Health. 2023;20(4):2790. [99] HOFFMANN K, SOBOL NA, FREDERIKSEN KS, et al. Moderate-to-High Intensity Physical Exercise in Patients with Alzheimer’s Disease: A Randomized Controlled Trial. J Alzheimers Dis. 2016;50(2):443-453. [100] 蔡春先,张运亮.运动改善大脑执行功能机制的研究进展[J].成都体育学院学报,2019,45(6): 120-126. [101] VERRET C, GUAY MC, BERTHIAUME C, et al. A physical activity program improves behavior and cognitive functions in children with ADHD: an exploratory study. J Atten Disord. 2012;16(1):71-80. [102] 史鹏,辛飞,张丁毅,等.体育运动促进儿童青少年执行功能效益的理论探新[J].武汉体育学院学报,2023,57(11):75-83. [103] SINK KM, ESPELAND MA, CASTRO CM, et al. Effect of a 24-Month Physical Activity Intervention vs Health Education on Cognitive Outcomes in Sedentary Older Adults: The LIFE Randomized Trial. JAMA. 2015;314(8):781-790. [104] RENTERÍA I, GARCÍA-SUÁREZ PC, MARTÍNEZ-CORONA DO, et al. Short-term high-Intensity interval training increases systemic brain-derived neurotrophic factor (BDNF) in healthy women. Eur J Sport Sci. 2020;20(4):516-524. [105] DE FREITAS MC, GEROSA-NETO J, ZANCHI NE, et al. Role of metabolic stress for enhancing muscle adaptations: Practical applications. World J Methodol. 2017;7(2):46-54. [106] FENG X, ZHANG Z, JIN T, et al. Effects of open and closed skill exercise interventions on executive function in typical children: a meta-analysis. BMC Psychol. 2023;11(1):420. [107] CHENG A, ZHAO Z, LIU H, et al. The physiological mechanism and effect of resistance exercise on cognitive function in the elderly people. Front Public Health. 2022;10:1013734. [108] GILSON ND, ANDERSSON D, PAPINCZAK ZE, et al. High intensity and sprint interval training, and work-related cognitive function in adults: A systematic review. Scand J Med Sci Sports. 2023;33(6):814-833. [109] MÜLLER P, DUDERSTADT Y, LESSMANN V, et al. Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity? J Clin Med. 2020;9(4):1136. [110] RESALAND GK, AADLAND E, MOE VF, et al. Effects of physical activity on schoolchildren’s academic performance: The Active Smarter Kids (ASK) cluster-randomized controlled trial. Prev Med. 2016;91:322-328. [111] WANG H, YANG Y, XU J, et al. Meta-analysis on the effects of moderate-intensity exercise intervention on executive functioning in children. PLoS One. 2023;18(2):e0279846. [112] CONTRERAS-OSORIO F, RAMIREZ-CAMPILLO R, CERDA-VEGA E, et al. Effects of Sport-Based Exercise Interventions on Executive Function in Older Adults: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2022;19(19):12573. [113] HILLMAN CH, ERICKSON KI, KRAMER AF. Be smart, exercise your heart: exercise effects on brain and cognition. Nat Rev Neurosci. 2008;9(1):58-65. [114] LUDYGA S, GERBER M, BRAND S, et al. Acute effects of moderate aerobic exercise on specific aspects of executive function in different age and fitness groups: A meta-analysis. Psychophysiology. 2016;53(11):1611-1626. [115] VERONESE N, FACCHINI S, STUBBS B, et al. Weight loss is associated with improvements in cognitive function among overweight and obese people: A systematic review and meta-analysis. Neurosci Biobehav Rev. 2017;72:87-94. [116] FJELL AM, WALHOVD KB. Structural brain changes in aging: courses, causes and cognitive consequences. Rev Neurosci. 2010;21(3):187-221. |
| [1] | Wang Dehua, Liang Chunting, Cheng Xiaofei, Li Sihui, Yao Xiaoduo, Tang Jiqin. Effects of different non-invasive brain stimulation modalities on unilateral spatial neglect after stroke: a network meta-analysis [J]. Chinese Journal of Tissue Engineering Research, 2026, 30(33): 8802-8810. |
| [2] | Fan Mengmeng, Ding Jiali, Wan Yujie, Huang Hailiang. A systematic review and network meta-analysis of neuromodulation techniques for promoting upper limb motor function after stroke [J]. Chinese Journal of Tissue Engineering Research, 2026, 30(28): 7494-7504. |
| [3] | Fang Enhui, Guan Hui, Ma Lihong. Non-invasive brain stimulation for core symptoms in children with autism spectrum disorder: a network meta-analysis [J]. Chinese Journal of Tissue Engineering Research, 2026, 30(24): 6373-6381. |
| [4] | Chen Ping, Du Jinchao, Wang Hongying, Zhang Hui, Wang Haixia. Different inspiratory muscle training methods improve exercise and cardiopulmonary function of patients after cardiac surgery: a network meta-analysis [J]. Chinese Journal of Tissue Engineering Research, 2026, 30(12): 3134-3144. |
| [5] | Wang Juan, Wang Guanglan, Zuo Huiwu. Efficacy of exercise therapy in the treatment of anterior cruciate ligament reconstruction patients: #br# a network meta-analysis #br# [J]. Chinese Journal of Tissue Engineering Research, 2025, 29(8): 1714-1726. |
| [6] | Tian Jinxin, Zhao Yuxin, Hu Tong, Cui Tiantian, Ma Lihong. Effects of different transcranial magnetic stimulation modes on refractory depression in adults: a network meta-analysis [J]. Chinese Journal of Tissue Engineering Research, 2025, 29(35): 7639-7648. |
| [7] | Zhao Yuxin, Zhang Deqi, Bi Hongyan. Effect of different stimulation modalities of non-invasive brain stimulation on cognitive function in patients with Parkinson’s disease: a network Meta-analysis [J]. Chinese Journal of Tissue Engineering Research, 2025, 29(24): 5212-5223. |
| [8] | Hu Tong, Li Xuan, Yuan Jing, Wang Wei. Different electromagnetic stimulation programs improve post-stroke dysphagia: a network Meta-analysis [J]. Chinese Journal of Tissue Engineering Research, 2025, 29(24): 5224-5236. |
| [9] | Liao Shuaixiong, Deng Kai, Bai Nan, Yang Wenliang, Wang Feng, Hao Zongji, Li Xueying. Mechanism by which exercise improves inhibitory control and drug craving in methamphetamine abstinent patients [J]. Chinese Journal of Tissue Engineering Research, 2024, 28(27): 4390-4396. |
| Viewed | ||||||
|
Full text |
|
|||||
|
Abstract |
|
|||||