Chinese Journal of Tissue Engineering Research ›› 2022, Vol. 26 ›› Issue (10): 1501-1504.doi: 10.12307/2022.194

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Effect of osteogenesis in patients with alveolar cleft after bone grafting investigated by volume analysis

Gu Yueguang1, Shen Jianhuan1, Ni Jieli2, Guo Shuyu2, Yan Zhongyi1, Zhang Yang2    

  1. 1Department of Stomatology, Lianyungang Hospital, Xuzhou Medical University, Lianyungang 222000, Jiangsu Province, China; 2Department of Orthodontics, Stomatological Hospital, Nanjing Medical University, Key Laboratory of Stomatological Disease of Jiangsu Province, Engineering Research Center for Translational Stomatology of Jiangsu Province, Nanjing 210029, Jiangsu Province, China 
  • Received:2021-05-11 Revised:2021-05-12 Accepted:2021-06-17 Online:2022-04-08 Published:2021-10-25
  • Contact: Zhang Yang, MD, Associate chief physician, Department of Orthodontics, Stomatological Hospital, Nanjing Medical University, Key Laboratory of Stomatological Disease of Jiangsu Province, Engineering Research Center for Translational Stomatology of Jiangsu Province, Nanjing 210029, Jiangsu Province, China Yan Zhongyi, MD, Attending physician, Department of Stomatology, Lianyungang Hospital, Xuzhou Medical University, Lianyungang 222000, Jiangsu Province, China
  • About author:Gu Yueguang, Master, Department of Stomatology, Lianyungang Hospital, Xuzhou Medical University, Lianyungang 222000, Jiangsu Province, China
  • Supported by:
    National Natural Science Foundation of China, No. 81700942 (to ZY); Jiangsu Province University Advantage Discipline Construction Project Foundation, No. 2018-87

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Abstract: BACKGROUND: Preserving bone after bone grafting in patients with alveolar cleft is crucial. Currently, most studies on alveolar cleft used two-dimensional measurement; only a single measurement evaluation method was used even if some studies used three-dimensional measurement using cone beam CT. The amount of bone formation measured varies greatly.
OBJECTIVE: To investigate the osteogenic effect in patients with alveolar cleft 1 year after bone grafting and to analyze the influencing factors such as canine eruption and preoperative defect size using cone beam CT combined with Mimics software. 
METHODS: Twenty-one patients with unilateral complete alveolar cleft were included. One year after the iliac bone grafting, the volume of the alveolar cleft defect in maxillary bone (the entire alveolar cleft defect area) and alveolar bone (near the defect area of the oral cavity) were measured by cone beam CT combined with Mimics software. The osteogenic effect of these two areas and whether the eruption of the canine affected the bone stock were analyzed. 
RESULTS AND CONCLUSION: (1) After bone transplantation, the amount of osteogenesis in the maxillary cleft defect was ralatively low, while the amount of osteogenesis in the alveolar ridge cleft defect was relatively high. The amount of osteogenesis was higher before the eruption of canine than that after the eruption of canine at the defect area (P < 0.05). There was no correlation between the postoperative osteogenic effect of the alveolar cleft defect area and the preoperative volume of the defect area. (2) The results showed that the osteogenic effect of the alveolar ridge defect area was higher than that of the whole defect area, and the alveolar ridge defect area should be taken as the basis to guide the subsequent orthodontic and prosthodontics treatment. Moreover, bone grafting should be performed before the eruption of canine.  

Key words: alveolar cleft, cone beam CT, bone grating, volume, orthodontics, stomatology, maxillary bone, Mimics software

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