Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (34): 6293-6296.doi: 10.3969/j.issn.1673-8225.2010.34.006

Previous Articles     Next Articles

Recombinant basic fibroblast growth factor/type I collagen composite materials repair meniscal cartilage injuries in avascular zone of rabbits

You Wei, Xiong Jian-yi, Cao Qing-li, Wang Da-ping, Xiao De-ming   

  1. Department of Orthopedic Trauma, Shenzhen Second People’s Hospital, Shenzhen   518035, Guangdong Province, China
  • Online:2010-08-20 Published:2010-08-20
  • Contact: Xiong Jian-yi, Master’s supervisor, Professor, Chief physician, Department of Orthopedic Trauma, Shenzhen Second People’s Hospital, Shenzhen 518035, Guangdong Province, China jianyixiong@126.com
  • About author:You Wei★, Master, Attending physician, Department of Orthopedic Trauma, Shenzhen Second People’s Hospital, Shenzhen 518035, Guangdong Province, China uv1997@139.com
  • Supported by:

    Science and Technology Projects of Shenzhen City, No. 200902033*

PDF

467

Abstract:

BACKGROUND: Meniscal cartilage injury in the avascular zone is not greatly influenced by alone application of recombinant basic fibroblast growth factor (rbFGF), which may be associated with in vivo absorption and degradation. At recent years, collagen type I has been increasingly applied as a biological carrier.
OBJECTIVE: To study the effect of rbFGF/collagen type I composite materials used in repairing meniscal cartilage injuries of rabbits.
METHODS: A total of 36 healthy New Zealand rabbits were randomly divided into three groups, including blank control group, rbFGF group and rbFGF/collagen type I group. Models of meniscus injuries in avascular area were established in rabbits. The animals were killed in 2, 6, 12 weeks postoperatively, and meniscus were taken and observed both grossly and microscopically.
RESULTS AND CONCLUSION: No significant healing effect was seen in rbFGF group, but proliferation promoting reaction on fibroblasts in synovial membrane at the margin of menisci did exist. The lesion within the avascular portion of the meniscus could be healed by using rbFGF/collagen type I. The reparative tissue was fibrocartilaginous which was different from the normal tissue. Results show a potential effective method of the avascular meniscal injuries repaired by the composite of rbFGF and collagen type I.

CLC Number: