Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (34): 6283-6286.doi: 10.3969/j.issn.1673-8225.2010.34.004

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Two kinds of bone materials for repairing rabbit calvarial bone defects: X-ray assessment

Yang Yi1, Zhao Cheng-chu2, Ma Zheng3, Zhao Feng2, Chen Hong-liang2, Sun Yong2   

  1. 1 Luzhou Medical College, Luzhou  646000, Sichuan Province, China; 2Department of Stomatology, Office Hospital of Chengdu Military Area Command of Chinese PLA, Chengdu   610011, Sichuan Province, China; 3Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Luzhou Medical College, Luzhou   646000, Sichuan Province, China
  • Online:2010-08-20 Published:2010-08-20
  • Contact: Sun Yong, Chief physician, Professor, Department of Stomatology, Office Hospital of Chengdu Military Area Command of Chinese PLA, Chengdu 610011, Sichuan Province, China
  • About author:Yang Yi★, Studying for master’s degree, Physician, Luzhou Medical College, Luzhou 646000, Sichuan Province, China y21023@hotmail.com

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Abstract:

BACKGROUND: At present, the ability of guiding new bone regeneration of the bio-derived and inorganic-derived bone tissue substitutes is verified, but their increased bony quantity guided and the osteopoietic effects have not been assured yet.
OBJECTIVE: To observe and contrast the ability, feature and difference of two bone substitute materials in guiding bone tissue regeneration during bone defect repairs.
METHODS: The hole-like calvarium defect models were established in 18 adult New Zealand rabbits. The front and back defects of the models were filled separately with inorganic-derived and bio-derived bone meals, then covered with collagen membranes. The blood clot between the cerebral dura mater and collagen membrane ware required to be retained. The repairing condition in the cranium defect areas was observed and analyzed in 12, 16 and 24 weeks postoperation by X-rays.
RESULTS AND CONCLUSION: The regenerating bony quantity increased along with time going, the quantity in the bio-group is obviously more than that of the inorganic-group in 12, 16 and 24 weeks postoperation (P ≤ 0.05). Inorganic-derived and bio-derived bone meal can both guide bony tissue regeneration and completely recover the calvarium defects. However, the bio-derived bone meal is better than the inorganic-derived meal.

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