Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (21): 3981-3984.doi: 10.3969/j.issn.1673-8225.2010.21.044

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Anesthesia-induced early-stage volume expansion effects of hydroxyethyl starch 130/0.4 versus modified fluid gelatin in patients undergoing coronary artery bypass graft

Zhang Yu, Xue Yu-liang, Wang Hong-wu   

  1. Department of Anesthesia, Cardiovascular Clinic College, Tianjin Medical University, Tianjin   300457, China
  • Online:2010-05-21 Published:2010-05-21
  • Contact: Xue Yu-liang, Master, Chief physician, Master’s supervisor, Department of Anesthesia, Cardiovascular Clinic College, Tianjin Medical University, Tianjin 300457, China xueyuliang@hotmail.com
  • About author:Zhang Yu★, Studying for master’s degree, Department of Anesthesia, Cardiovascular Clinic College, Tianjin Medical University, Tianjin 300457, China 47504383@qq.com

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Abstract:

BACKGROUND: The understanding of volume expansion effect of different colloid solutions in critical ill patient or during crucial period of anesthesia is immediately needed.
OBJECTIVE: To analyze the dynamic changes of colloid osmotic pressure and hemoglobin concentration before and after colloid solution infusions, to establish setting equations and estimate intravascular volume according to principle of conservation of mass, and to compare the effect of hydroxyethyl starch 130/0.4 and modified fluid gelatin on volume expansion early after induction.
METHODS: Thirty patients scheduled for coronary artery bypass graft, received either 7 mL/kg hydroxyethyl starch 130/0.4 or 7 mg/kg modified fluid gelatin within 10 minutes after induction. Colloid osmotic pressure, hemocrit, hemoglobin concentration and mean artery pressure were measured at 3 time points: before colloid fluid infusion, immediate after infusion and 1 hour after infusion. Intravascular volume (V(0), V(1), V(2)), expanded blood volume (V△1, V△2) and volume expansion rate (V△1/V(infusion)) immediately after colloid fluid infusion were calculated by equations.
RESULTS AND CONCLUSION: There was no significant difference of mean artery pressure between groups at each time point (P > 0.05). V(1) > V(0) in both groups (P < 0.05). V△1/V(infusion) was higher than 100% in both groups (P < 0.05), however, no difference of V△1/V(infusion) was found between groups (P > 0.05). V(1) and V(2) was comparable in modified fluid gelatin group (P > 0.05), however V(2) was higher than V(1) in hydroxyethyl starch 130/0.4 group (P < 0.05). The results above demonstrate that both hydroxyethyl starch 130/0.4 and modified fluid gelatin have a strong immediate volume expansion ability, as well as produced a shift of solution from extravascular space to intravascular space, but hydroxyethyl starch 130/0.4 has a slightly greater volume persistence than modified fluid gelatin, however this slight difference does not significantly affect the hemodynamic feature of both groups.

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