Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (21): 3878-3882.doi: 10.3969/j.issn.1673-8225.2010.21.018

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Application of biological materials in the reconstruction of cruciate ligament injuries

Yang Hong-tao1, Lang Ming-mei2, Zhao Qian-qi 3, Wang Xiang-dong1, Pan Jia-bin1   

  1. 1 Department of Physical Education, Hebei Normal University, Qinhuangdao   066004, Hebei Province, China; 2 Department of Physical Education, Hebei Vocational and Technical College of Building Materials, Qinhuangdao   066004, Hebei Province, China; 3 Department of Physical Education, Hebei Institute of Physical Education Shijiazhuang  050041, Hebei Province, China
  • Online:2010-05-21 Published:2010-05-21
  • About author:Yang Hong-tao★, Master, Lecturer, Department of Physical Education, Hebei Normal University, Qinhuangdao 066004, Hebei Province, China mabaoling528@163.com

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Abstract:

OBJECTIVE: To summarize the research progress of reconstructing the cruciate ligaments of knee joint, and to emphasize the type of knee injury, main biological materials and research progress of knee ligament reconstruction.
METHODS: Using “cruciate ligament reconstruction, biological materials, artificial ligaments, tissue engineering” as the Chinese keywords, “cruciate ligament, LARS artificial ligament, ligament reconstruction” as the English keywords, a computer search was performed on China Academic Full-text Journal and PubMed database between January 1993 and February 2010. Inclusive criteria: articles related to the biological materials, cruciate ligament reconstruction, artificial ligaments, and tissue engineering; exclusive criteria: repeated study or Meta analysis articles were excluded. A total of 35 articles with the main focus to discuss the types and properties of biological materials applied in knee cruciate ligament reconstruction.
RESULTS: Through the analysis of knee injury, the common knee damage is mainly ligament injury, and surgical reconstruction is the predominant approach to restore its function. Secondly, after the main materials of the knee cruciate ligament reconstruction are analyzed, biological materials are proved to exhibit a good application prospect in knee ligament reconstruction, but we must analyze the characteristics of various biological materials and make use of their advantages in practice. The synthetic material artificial ligament may lead to a failure because of poor histocompatibility and fatigue-caused fracture; autologous grafts often exhibit complications at the donor site and fixation problem; allografts always exhibit propagation of diseases, immune response, delayed healing and infection, etc.; to achieve good results during tissue cell differentiation and factor regulation, we should integrate the separation and culture of the seeds, the choice and construction of the scaffold materials, and supplementing cytokines and surface modification together.
CONCLUSION: The analysis of the major materials for knee ligament reconstruction is the basis of treating knee joint injury and disease.

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