Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (16): 2903-2906.doi: 10.3969/j.issn.1673-8225.2010.16.014

Previous Articles     Next Articles

Biocompatibility of electro-spinning beta-tricalcium phosphate/gelatin guided tissue regeneration membrane versus polylactic acid and poly(lactide-co-glycolide) membrane

Zheng Jun-yuan1, Tang Ming1, Deng Xu-liang2, Yang Xiao-ping3, Zhang Shen3, Li Xiao-xia1   

  1. 1 Department of Stomatology, First Affiliated Hospital, Chongqing Medical University, Chongqing  400016, China; 2 School of Stomatology, Peking University, Beijing 100081, China, 3 Composites Center, Beijing University of Chemical Technology, Beijing 100029, China
  • Online:2010-04-16 Published:2010-04-16
  • Contact: Tang Ming, Master, Associate professor, Department of Stomatology, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China doctor-mt@hotmail.com
  • About author:Zheng Jun-yuan★ Studying for master’s degree, Department of Stomatology, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China weiweig5yy@163.com

PDF

440

Abstract:

BACKGROUND: In the past, guided tissue regeneration materials were produced by β-tricalcium phosphate (β-TCP) and gelatin (Gel), but the production of fiber membrane by electro-spinning technique was reported less.
OBJECTIVE: To prepare a new kind of Gel with β-TCP hybrid nanofibrous membrane and testing its biocompatibility compared with polylactic acid (PLLA) and poly(lactide-co-glycolide) (PLGA) membrane.
METHODS: The β-TCP/Gel guided tissue regeneration membrane was made by electro-spinning technique. Scanning electron microscopy (SEM) was employed to observe membrane surface. MTT test was performed to compare toxicity among β-TCP/Gel, PLLA, and PLGA membranes.
RESULTS AND CONCLUSION: The β-TCP/Gel membrane was porous, and β-TCP granules were nodosity-adhered on surface of Gel. The average diameter of fiber was 500-600 nm. The distribution of fiber ranged from 200 to 500 nm. There was no significant difference in toxicity among PLLA, PLGA, and negative control group (P > 0.05). The results suggested that the β-TCP /Gel membrane was low cytotoxicity and suitable for tissue engineering. It would be a promising material for periodontal tissue regeneration.

CLC Number: